You Position: Home > Paper
Study on nucleotidoids from n-butyl alcohol part of sponge Cinachyrella australiensis
( views:207, downloads:0 )
- Author:
- No author available
- Journal Title:
- CHINESE TRADITIONAL AND HERBAL DRUGS
- Issue:
- 11
- DOI:
- 10.3321/j.issn:0253-2670.2004.11.004
- Key Word:
- 海绵;分离提取;结构鉴定
Abstract： 目的对中国南海产海绵Cinachyrella australiensis的正丁醇部分化学成分进行了系统分离,为合理开发海洋药物资源,更好地利用海洋生物体内具有强生理活性的化学成分,从而开发出适用于人体的安全有效的药物.方法采用多种色谱方法进行分离纯化,应用波谱分析技术,并结合文献对照,对所分离到的化合物进行了结构鉴定.结果共分离得到7个化合物,其结构分别为:2-甲基-6-氨基嘌呤脱氧核苷[2-methyl-6-amino-9-(2-deoxy-β-D-ribofuranosyl)-purine,I]、6-氨基嘌呤脱氧核苷(2′-deoxyadenosne,Ⅱ)、6-氨基嘌呤核苷(6-amino-9-β-D-ribofuranosyl-9H-punne,Ⅲ)、尿嘧啶(uracill,Ⅳ)、胸腺嘧啶(thymine,Ⅴ)、胸腺嘧啶脱氧核苷(thymidine,Ⅵ)、尿嘧啶脱氧核苷[1-(2-deoxy-β-D-ribofuranosyl)uracil,Ⅶ].结论对中国南海海绵正丁醇部分的化学成分进行了报道,系统地分离出了2大类核苷类化合物.
- [1]M, Kobayashi,T, Okamoto,K, Hayashi,etc.Marine natural products. XXXII. Absolute configurations of C-4 of the manoalide family, biologically active sesterterpenes from the marine sponge Hyrtios erecta.[J].1994,42(2).
- [2]M.L. Bourguet-Kondracki,M.T. Martin,C. Debitus,etc.12-epi-heteronemin: New sesterterpene from the marine sponge Hyrtios erecta[J].1994,35(1).
- [3]JohnH.CardellinaII,ClintonJ.Graden,BradleyJ.Greer,etc.17Z-Tetracosenyl 1-glycerol ether from the spongesCinachyra allocladaandUlosa ruetzleri[J].1983,18(2).
- [4]Jun'ichi Kobayashi,Tetsuya Murayama,Masami Ishibashi,etc.Hyrtiosins A and B, new indole alkaloids from the Okinawan marine sponge Hyrtios erecta[J].1990,46(23).
- [5]P D, Ellis,R B, Dunlap,A L, Pollard,etc.Carbon-13 nuclear magnetic resonance of 5-substituted uracils.[J].1973,95(13).
- [6]Mitome H.,Nishijima S.,Yamada Y.,etc.Three new scalarane sesterterpenoids from the Okinawan sponge Hyrtioserectus[J].2000,63(10).
- [7]Kazuo Iguchi,Yoshie Shimada,Yasuji Yamada.Hyrtiosal, a new sesterterpenoid with a novel carbon skeleton from the Okinawan marine sponge Hyrtios erectus[J].1992,57(2).
- [8]M, Kobayashi,S, Aoki,K, Gato,etc.Marine natural products. XXXIV. Trisindoline, a new antibiotic indole trimer, produced by a bacterium of Vibrio sp. separated from the marine sponge Hyrtios altum.[J].1994,42(12).