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Chemical constituent as inhibitor to prolyl endopeptidase from underground part of cultivated Rhodiola sachalinensis
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- Author:
- No author available
- Journal Title:
- CHINESE TRADITIONAL AND HERBAL DRUGS
- Issue:
- 8
- DOI:
- 10.3321/j.issn:0253-2670.2004.08.005
- Key Word:
- 高山红景天;脯酰肽内切酶;红景天苷
Abstract： 目的研究人工种植高山红景天中具有较强的脯酰肽内切酶(prolyl endopeptidase,PEP)抑制活性的化学成分.方法人工种植高山红景天用甲醇提取,不同极性溶剂分级萃取,分别用硅胶和Sephadex LH-20柱色谱分离,测定化合物的理化常数和波谱数据,鉴定化合物结构.结果从人工种植高山红景天甲醇提取物的醋酸乙酯萃取部分分离得到8个单体化合物:没食子酸(Ⅰ)、红景天苷(Ⅱ)、7-O-β-D-葡萄糖-3,4',5,8-四羟基黄酮(Ⅲ)、红景天黄酮苷(Ⅳ)、表儿茶素(Ⅴ)、表儿茶素没食子酸(Ⅵ)、红景天氰苷A(Ⅶ)、β-D-葡萄糖-3,7-二甲基-4-羟基-2,6-辛二烯(Ⅷ).结论首次从人工种植红景天分离出显示较强的PEP抑制活性组份中分离出8个单体化合物.
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