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Significance of metabonomics in modern research of Chinese materia medica
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- Author:
- No author available
- Journal Title:
- CHINESE TRADITIONAL AND HERBAL DRUGS
- Issue:
- 6
- DOI:
- 10.3321/j.issn:0253-2670.2004.06.001
- Key Word:
- 代谢物组学;新药研究开发;药物筛选;药物安全性;中药
Abstract： 代谢物组学是后基因时代出现的一门新兴"组学"学科.它能用反映整体的代谢物图直接认识生理和生化状态,因此能提供区别于其他"组学"而来的大量信息.代谢物组学已经用于评价实验动物模型和外源物产生的一系列代谢过程和作用机制、靶器官的效应、组织损伤.代谢物组学是新药研究开发的必要一部分,其应用涵盖新生物标志物的发现、新药筛选、安全性实验和作用机制研究.因此,在模型识别和确证、药物筛选、作用机制研究等方面具有理论意义和应用价值.在现代中药研究中,同样具有应用前景.
- [1]Orphanides G.Toxicogenomics: challenges and opportunities.[J].2003,140/141(0).
- [2]J C, Venter,M D, Adams,E W, Myers,etc.The sequence of the human genome.[J].2001,291(5507).
- [3]Plumb RS.,Stumpf CL.,Haselden JN.,etc.Metabonomics: the use of electrospray mass spectrometry coupled to reversed-phase liquid chromatography shows potential for the screening of rat urine in drug development[J].2002,16(20).
- [4]Mendrick DL,Castle AL,Carver MP.Toxicogenomics: a new revolution in drug safety.[J].2002,7(13).
- [5]Robertson D,Beckonert O,Keun H,etc.Contemporary issues in toxicology the role of metabonomics in toxicology and its evaluation by the COMET project.[J].2003,187(3).
- [6]Nicholson JK,Lindon JC,Holmes E.'Metabonomics': understanding the metabolic responses of living systems to pathophysiological stimuli via multivariate statistical analysis of biological NMR spectroscopic data.[J].1999,29(11).
- [7]Plumb RS.,Stumpf CL.,Castro-Perez J.,etc.Use of liquid chromatography/time-of-flight mass spectrometry and multivariate statistical analysis shows promise for the detection of drug metabolites in biological fluids[J].2003,17(23).
- [8]Reo NV.NMR-based metabolomics.[J].2002,25(4).
- [9]J. Robert Espina,John P. Shockcor,William J. Herron,etc.Detection of in vivo biomarkers of phospholipidosis using NMR-based metabonomic approaches[J].2001,39(9).
- [10]Holmes E,Lindon JC,Nicholson JK.Metabonomics and its role in drug development and disease diagnosis.[J].2004,4(2).
- [11]Julian L Griffin.Metabonomics: NMR spectroscopy and pattern recognition analysis of body fluids and tissues for characterisation of xenobiotic toxicity and disease diagnosis[J].2003,7(5).