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Sampsoniones and xanthones of Hypericum sampsonii from Yunnan Province
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- Author:
- No author available
- Journal Title:
- CHINESE TRADITIONAL AND HERBAL DRUGS
- Issue:
- 2
- DOI:
- 10.3321/j.issn:0253-2670.2004.02.005
- Key Word:
- 元宝草;细胞毒性;元宝草酮;(口山)酮
Abstract： 目的研究金丝桃属植物元宝草Hypericum sampsonii 全株的化学成分,并通过药理试验寻找活性成分(或组份).方法在细胞毒筛选结果指导下,同步对元宝草活性部位进行化学成分分离纯化.硅胶为吸附剂,多次柱色谱、重结晶;并通过理化数据测定及波谱分析,鉴定化合物结构.结果分离鉴定出6种成分,分别是:1-苯甲酰基-3-(3-甲基-2-丁烯基)-6,6,13,13-四甲基-11-香叶基-5-唑四环[7.3.1.03,7.04,11]十三烷-2,12-二酮(元宝草酮A,Ⅰ);1-苯甲酰基-5-(1-羟基-异丙基)-6,6,13,13-四甲基-11-香叶基-四环[7.3.1.1.03,7]十四烷-2,12,14-三酮(元宝草酮F,Ⅱ);3-(1-羟基-5-甲基-4-己烯基)-6,10-二(3-甲基-2-丁烯基)-8-苯甲酰基-9,9-二甲基-4-唑三环[6.3.1.01,5]-5-十二碳烯-7,12-二酮(元宝草酮K,Ⅲ);1,2-二氢-3,6,8-三羟基-1,1-双(3-甲基-丁-2-烯基)--2,9-酮(金丝梅酮,Ⅳ);1,7-二羟基-4-甲氧基（口山）酮(Ⅴ)及1,3,6,7-四羟基-8-(3-甲基-丁-2-烯基)（口山）酮(Ⅵ).结论化合物Ⅳ～Ⅵ为首次从该植物中分离得到.另外,通过细胞毒试验发现,滇产元宝草的氯仿及醋酸乙酯提取物具有抗癌活性.
- [1]王杨,王世盛,周丹红,等.植物（口山）酮类化合物的波谱特征[J].2002,(5).
- [2]Hanne Nielsen,Peter Arends.Xanthone Constituents of Hypericum androsaemum[J].1979,42(3).
- [3]Hu LH.,Sim KY..Sampsoniones A-M, a unique family of caged polyprenylated benzoylphloroglucinol derivatives, from Hypericum sampsonii[J].2000,56(10).
- [4]Ishiguro K,Nagareya N,Suitani A,etc.A prenylated xanthone from cell suspension cultures of Hypericum patulum.[J].1997,44(6).
- [5]Hu LH.,Sim KY..Sampsoniones C-H, a unique family of polyprenylated benzophenone derivatives with the novel tetracyclo[7.3.1.1(3,11).0(3,7)]tetradecane-2,12,14-trione skeleton, from Hypericum sampsonii (Guttiferae)[J].1999,40(4).
- [6]R. Pedro Jos\ufffd,Cardona Luz,Fern\ufffddez Isabel.Xanthone Constituents of Hypericum inodorum[J].1992.