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Study on aescin metabolism in intestinal flora in vitro

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Author:
No author available
Journal Title:
CHINESE TRADITIONAL AND HERBAL DRUGS
Issue:
11
DOI:
10.3321/j.issn:0253-2670.2003.11.004
Key Word:
七叶皂苷;七叶树属;肠内菌群

Abstract: 目的通过离体实验观察人肠道内细菌对七叶皂苷的代谢.方法离体培养人肠道内细菌,与七叶皂苷厌氧温孵,采用硅胶柱色谱和制备型高效液相色谱等方法对七叶皂苷的肠菌代谢产物进行分离和代谢转化产物的鉴定.结果代谢产物经IR、MS和NMR鉴定为:21β-巴豆酰基原七叶皂苷元(Ⅰ),21β-当归酰基原七叶皂苷元(Ⅱ),21β-巴豆酰基-22α-乙酰基原七叶皂苷元(Ⅲ),21β-当归酰基-22α-乙酰基原七叶皂苷元(Ⅳ).其中Ⅲ和Ⅳ为首次发现的新天然产物.结论在离体条件下,七叶皂苷可被人肠内菌代谢为21β-巴豆酰基原七叶皂苷元(Ⅰ)、21β-当归酰基原七叶皂苷元(Ⅱ),21β-巴豆酰-22α-乙酰基原七叶皂苷元(Ⅲ)、21β-当归酰基-22α-乙酰基原七叶皂苷元(Ⅳ).

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