Abstract: Object To study the chemical constituents of the leaves of Isodon eriocalyx (Dunn) Hara var. laxiflora C. Y. Wu et H. W. Li. Methods The leaves of I. eriocalyx var. laxiflora were extracted with 70% Me2CO, and separated and purified by column chromatographies on silica gel or MCI gel. All the compounds were identified on the basis of spectral analysis (including 1D and 2D NMR and MS) or direct co-chromatographies with authentic samples. Results Fifteen compounds were isolated from I. eriocalyx var. laxi flora. Their structures were characterized as blumenol A ( Ⅰ ), 2-formyl-5-hydroxymethylfuran ( Ⅱ ), 3, 4-dihydroxyphenacyl alcohol ( Ⅲ ), caffeic acid ( Ⅳ ), caffeic acid ethylene ester ( Ⅴ ), p-hydroxybenzoic acid ( Ⅵ ), m-hydroxybenzoic acid ( Ⅶ ), p-methylbenzoic acid (Ⅷ), 3, 4-dimethoxyphenol ( Ⅸ ), rosmanic acid ( Ⅹ ), rosmanic acid methyl ester ( Ⅺ ), cirsimaritin ( Ⅻ ), 8-hydroxycirsimaritin ( ⅩⅢ ), ursolic acid ( ⅩⅣ ), and 2α-hydroxyursolic acid ( ⅩⅤ ) respectively. Conclusion Compounds Ⅰ - Ⅴ , Ⅷ, Ⅸ and Ⅺ were isolated from this plant for the first time.