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Studies on chemical constituents of Diploclisia glaucescens
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- Author:
- No author available
- Journal Title:
- CHINESE TRADITIONAL AND HERBAL DRUGS
- Issue:
- 2
- DOI:
- 10.3321/j.issn:0253-2670.2003.02.002
- Key Word:
- 苍白秤钩风;化学成分;药理活性
Abstract： 目的为了进一步揭示中药苍白秤钩风Diploclisia glaucescens药理活性的物质基础,研究并开发其活性成分,对采自广西的苍白秤钩风藤茎的化学成分进行了系统研究.方法经硅胶、反相硅胶和Sepadex LH-20反复柱层析分离纯化并通过波谱分析鉴定了9个化合物的结构.结果9个化合物分别被鉴定为:(2,3)反式-N-对羟基苯乙基阿魏酰胺(Ⅰ),1,5-二羟基-3-甲基-蒽醌(Ⅱ),商陆酸-3-O-β-D葡萄糖醛酸-28-O-β-D-葡萄糖苷(Ⅲ),商陆酸-3-O-β-D-葡萄糖-28-O-β-D-葡萄糖苷(Ⅳ),商陆酸-3-O-β-D葡萄糖醛酸苷(Ⅴ),商陆酸-3-O-β-D葡萄糖苷(Ⅵ),豆甾醇(Ⅶ),豆甾醇-3-O-β-D葡萄糖苷(Ⅶ),3-甲氧基-4-羟基-苯甲酸(Ⅸ).结论化合物Ⅰ,Ⅱ为首次从本属植物中分离得到,通过仔细解析Ⅱ的二维相关谱(1H-1HCOSY,HMQC,HMBC),对化合物Ⅱ的碳谱数据进行了重新归属.药理实验表明化合物Ⅰ具有较好的免疫增强活性,化合物Ⅳ～Ⅵ有也具有一定的免疫增强活性.
- [1]Sedat Imre,Aysel Öztunç,Nadir Büyüktimkin.Ziganein und ziganein-1-methyläther: Zwei neue anthrachinone aus Digitalis schischkinii[J].1974,13(3).
- [2]R W, Miller,J, Clardy,J, Kozlowski,etc.Phytoecdysteroids of Diploclisia glaucescens seed.[J].1985,(1).
- [3]Virbala C. Shah,Adolf S. D'sa,Noel J.de Souza.Chonemorphine, stigmasterol, and ecdysterone: Steroids isolated through bioassay-directed plant screening programs[J].1989,53(3-5).
- [4]B.M.Ratnayake Bandara,Lalith Jayasinghe,Veranja Karunaratne,etc.Ecdysterone from stem of Diploclisia glaucescens[J].1989,28(4).
- [5]Xue Zhao Lu,Wen Hao Xu,Hideo Naoki.Anthraquinones from Salvia przewalskii[J].1992,31(2).
- [6]Mehdi H. Kazmi,Abdul Malik,Saira Hameed,etc.An anthraquinone derivative from Cassia italica[J].1994,36(3).
- [7]Bandara B.,Jayasinghe U.,Karunaratne V.,etc.Triterpenoidal Constituents of Diploclisia glaucescens[J].1990.
- [8]Hellwing V,Breitmaier E,Munoz O,etc.Tropane Alkaloids from Schizanthus Litoralis[J].1996,43(3).
- [9]Sedat Imre,Nadir Büyüktimkin.Zwei neue anthrachinone aus den wurzeln von Digitalis orientalis[J].1975,14(10).
- [10]B.M. Ratnayake Bandara,Lalith Jayasinghe,Veranja Karunaratne,etc.Diploclisin, a bidesmosidic triterpenoid saponin from Diploclisia glaucescens[J].1989,28(10).