You Position: Home > Paper

Synthesis and protective effect of zinc chlorin P6-6-N-ethylamide-7,γ-dimethylester on indomethacin-induced gastric ulcer in rats

( views:540, downloads:0 )
Author:
No author available
Journal Title:
CHINESE TRADITIONAL AND HERBAL DRUGS
Issue:
6
DOI:
10.3321/j.issn:0253-2670.2002.06.003
Key Word:
蚕沙;叶绿素;合成;二氢卟吩P6-6-(N-乙基)酰胺-7,y-二甲酯锌;溃疡

Abstract: 目的研究二氢卟吩P6-6-(N-乙基)酰胺-7,γ-二甲酯锌(I)的合成及抗胃溃疡活性.方法蚕沙糊状叶绿素经酸、碱降解反应制得紫红素-18(Ⅲ),Ⅲ经乙胺解后重氮甲烷甲基化制得二氢卟吩P6-6-(N-乙基)酰胺-7,γ-二甲酯(Ⅱ),Ⅱ与醋酸锌络合制得I;以0.2%吲哚美辛(20 mg/kg)ip大鼠制备胃溃疡模型,并测定溃疡指数和溃疡个数.结果I的结构经UV、IR、1HNMR、FAB-MS及元素发射光谱确证.ip I 80 mg/kg有极显著降低吲哚美辛诱发的大鼠溃疡指数(P<0.01)和溃疡个数(P<0.01).结论I为新化合物,Ⅱ的波谱数据系首次报道.I对吲哚美辛诱发的大鼠胃溃汤具有显著的保护作用,提示I是一种有开发前景的抗溃疡候选化合物,值得深入研究.

WanfangData CO.,Ltd All Rights Reserved
About WanfangData | Contact US
Healthcare Department, Fuxing Road NO.15, Haidian District Beijing, 100038 P.R.China
Tel:+86-010-58882616 Fax:+86-010-58882615 Email:yiyao@wanfangdata.com.cn