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Studies on antishock effect of active constituents in GINSENG SINI TANG
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- Author:
- No author available
- Journal Title:
- CHINESE TRADITIONAL AND HERBAL DRUGS
- Issue:
- 5
- DOI:
- 10.3321/j.issn:0253-2670.2002.05.003
- Key Word:
- 人参四逆汤;抗休克;人参皂苷
Abstract： 目的分析人参四逆汤抗失血性休克作用的提取组分S-1和S-7的组成成分.方法结合硅胶色谱柱分离,利用ESI/MSn、MALDI-TOF/MS等技术分析鉴定S-1和S-7的化学成分.结果从人参四逆汤水煎液的抗休克作用的有效组分S-7中分析和鉴定了人参皂苷-Ra1、-Ra2、-Rb1、-Rb2、-Rba、-Rc、-Rd、-Re、-Rg1、-Rg2、-Rg3、-Rf等12种人参皂苷;从有效组分S-1中检出下列二萜生物碱成分:苯甲酰次乌头碱油酸酯(14-benzoylhypaconine-8-linoleate, HAL)、苯甲酰去氧乌头碱油酸酯(14-benzoyldeoxyaconine-8-oleate, HAO)、苯甲酰次乌头碱棕榈酸酯(14-benzoylhypaconine-8-palmitate, HAP)、苯甲酰中乌头碱(benzoylmesaconitine, BM)、苯甲酰乌头碱(benzoylaconitine,BA)、苯甲酰次乌头碱(benzoylhypaconitine, BH) .结论首次分析鉴定了人参四逆汤水煎液抗失血性休克作用的提取组分的化学成分.
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