You Position: Home > Paper
Inhibition Effect of Honggumycin on Drug Resistance R Plasmid Transfer Between Bacteria
( views:39, downloads:0 )
- Author:
- No author available
- Journal Title:
- Chinese Journal of Applied & Environmental Biology
- Issue:
- 1
- DOI:
- 10.3724/SP.J.1145.2012.00153
- Key Word:
- 红谷霉素;R质粒;细菌耐药性;质粒转移
Abstract： 以Shigella flexneri D15 R-plasmid CmR和Escherichia coil 1485 RifR为试验菌株,研究红谷霉素对细菌耐药性质粒在细菌之间转移的抑制作用及对两种细菌R质粒的消除作用.将红谷霉素( 30μg/mL)与S.flexneri D15 R-plasmid CmR和E.coli 1485 RifR按实验设计混合并分别培养24 h和48 h,涂布在麦康凯琼脂平板上,计算相应菌落数.结果表明,当红谷霉素抑菌浓度为30 μg/mL时,对细菌耐氯霉素的R质粒的转移抑制率分别达到92.82％(24 h培养)和96.04％ (48 h培养),但对R质粒的消除作用不显著.说明红谷霉素对R质粒转移抑制作用强烈但不具有R质粒的消除作用.
- [1]魏赛金,钟敏,黄林,等.链霉菌702所产抗细菌组分S2的分离纯化[J].2006,(3).
- [2]黎循航,刘姝,涂国全.链霉菌702所产生物活性物质抑菌活性的初步研究[J].2002,(6).
- [3]钟敏,童孝田,孙宇辉,等.链霉菌702所产抗细菌组分S2的化学结构鉴定[J].2007,(3).
- [4]D R, Sharma,B, Pradhan,S K, Mishra.Multiple drug resistance in bacterial isolates from liquid wastes generated in central hospitals of Nepal.[J].1900,8(29).
- [5]D, Raghunath.Emerging antibiotic resistance in bacteria with special reference to India.[J].2008,33(4).
- [6]Jensen SO,Skurray RA,Firth N,etc.Analysis of the prototypical Staphylococcus aureus multiresistance plasmid pSK1.[J].2010,64(3).
- [7]Waters VL.Conjugation between bacterial and mammalian cells.[J].2001,29(4).
- [8]R V, Miller.Bacterial gene swapping in nature.[J].1998,278(1).
- [9]Grohmann E,Muth G,Espinosa M.Conjugative plasmid transfer in gram-positive bacteria.[J].2003,67(2).
- [10]Conner, C. P.,Heithoff, D. M.,Mahan, M. J..In Vivo Gene Expression: Contributions to Infection, Virulence, and Pathogenesis[J].1998,1(225).
- [11]陈天寿主编.微生物培养基的制造与应用[M].1995.
- [12]Mark A, Toleman,Peter M, Bennett,Timothy R, Walsh.Common regions e.g. orf513 and antibiotic resistance: IS91-like elements evolving complex class 1 integrons.[J].2006,58(1).
- [13]Joon-Hee Lee,Kang-Lok Lee,Won-Sik Yeo,etc.SoxRS-mediated lipopolysaccharide modification enhances resistance against multiple drugs in Escherichia coli.[J].2009,191(13).
- [14]J, Hrabák,A, Zemanová,E, Chudácková.[Mobile genetic elements in the epidemiology of bacterial resistance to antibiotics].[J].2010,59(2).
- [15]Garg SK.,Ramteke PW.,Verma T..Effect of ecological factors on conjugal transfer of chromium-resistant plasmid in Escherichia coli isolated from tannery effluent[J].2002,102/103(0).
- [16]H, Ochman,J G, Lawrence,E A, Groisman.Lateral gene transfer and the nature of bacterial innovation.[J].2000,405(6784).
- [17]De Lencastre H,Tomasz A,Oliveira D.Antibiotic resistant Staphylococcus aureus: a paradigm of adaptive power[J].2007,10(5).
- [18]Ashkenazi S,Kazaronovski V,Samra Z,etc.Growing antimicrobial resistance of Shigella isolates.[J].2003,51(2).
- [19]张晓莉.关于细菌耐药的机理、监控及对策的研究进展[J].1997,(1).
- [20]W H, Zhao,Z Q, Hu,Y, Hara,etc.Inhibition by epigallocatechin gallate (EGCg) of conjugative R plasmid transfer in Escherichia coli.[J].2001,7(3).