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Influence of tRNA Gene Duplication and Loss within Amphibian Mitochondrial Genome

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Author:: No author available

Journal Title:: CHINESE JOURNAL OF APPLIED & ENVIRONMENTAL BIOLOGY

Issue:: 6

DOI:: No doi available

Key Word:: 两栖类;线粒体基因组;密码子使用偏好;tRNA基因重复;tRNA基因丢失

Abstract：在脊椎动物线粒体基因组中,偶有tRNA基因重复或丢失事件发生,这些事件因与相应氨基酸转运密切关联而凸显重要.两栖类中,这些重复或丢失相对多样,可为相关研究提供良好素材.为了解这些事件对氨基酸对应的密码子使用偏好是否产生影响,本文引入统计方法,检测10种两柄类mtDNA蛋白编码基因相对的同义密码子使用度(RSCU),并特别设计将发生tRNA基因重复或丢失物种与其近缘群进行对比分析.结果显示,tRNA基因的重复对密码子使用偏好没有显著的影响,推测可能与突变积累的时限和mtDNA紧凑性有关.另外,tRNA基因丢失也未使相应氨基酸密码子使用偏好产生明显的改变.推测在两栖类中,"tRNA转入"和"tRNA反密码子摆动位点的超级摆动"可能是tRNA基因丢失的补偿方式.

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