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Genomics and synthetic biology of traditional Chinese medicine

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Author:: No author available

Journal Title:: Acta Pharmaceutica Sinica

Issue:: 8

DOI:: No doi available

Key Word:: 中药;基因组学;合成生物学;基因组标记

Abstract：中药基因组学与合成生物学是目前中药现代化研究中的热点领域.中药基因组学研究主要包括中药转录组学、结构基因组学、基因组标记解析和功能基因组学等,旨在通过对中药原物种遗传信息的揭示,解析重要活性产物的生物合成途径,发掘参与生物合成的功能基因,推动对中药合成生物学、基因组辅助分子鉴定和分子育种及中药道地性遗传机制阐释的深入研究.基因组学及其相关研究大幅提升了人类对于生命过程的认知和按照需求合成或改造生命的能力.中药合成生物学是在中药基因组学研究的基础上,对中药有效成分生物合成相关元器件进行发掘和表征,借助工程学原理对其进行设计和标准化,通过在底盘细胞中装配与集成,重建生物合成途径和代谢网络,实现药用活性成分的定向、高效的异源合成,从而提升我国创新性药物的研发能力和医药产业的国际核心竞争力.

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