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In vitro and in vivo evaluation of total flavones of hippophae rhamnoides self-microemulsifying drug delivery system
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- Author:
- No author available
- Journal Title:
- Acta Pharmaceutica Sinica
- Issue:
- 8
- DOI:
- No doi available
- Key Word:
- 醋柳黄酮;自微乳化给药系统;性质;分散性;小肠吸收;生物利用度
Abstract： 本文的目的在于对醋柳黄酮自微乳化给药系统进行评价,该给药系统用于提高难溶性药物醋柳黄酮的口服生物利用度.评价指标包括自微乳化时间、粒径及多分散指数、形态学特征、体外分散性、稳定性、在体小肠吸收及生物利用度.结果表明,该自微乳化给药系统在3 min内即形成微乳,平均粒径低于40 nm,多分散指数低于0.2,电镜下观察粒子形态为球形；20 min时体外累积释放百分率(以槲皮素计)接近90％,显著高于普通胶囊剂；加速试验条件下放置6个月,自微乳化给药系统的所有指标均未发生明显改变；该自微乳化给药系统的在体小肠吸收速率常数(以槲皮素计)显著高于醋柳黄酮乙醇溶液(P＜0.05)；以醋柳黄酮的混悬液为参比制剂,自微乳化给药系统的大鼠灌胃给药相对生物利用度(以槲皮素计)为518％.
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