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Research progress in co-delivery of gene and chemotherapy drugs with cationic liposome carrier for cancer therapy

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Author:: No author available

Journal Title:: Acta Pharmaceutica Sinica

Issue:: 8

DOI:: No doi available

Key Word:: 阳离子脂质体;基因;化疗药物;共载;肿瘤治疗

Abstract：尽管传统癌症化疗方法已取得明显的进展,但由于化疗药物的多药耐药性及毒副作用限制其应用.为了克服多药耐药性,需要增加药物剂量及用药次数,反而导致更强的毒副作用,最终限制了化疗药物的临床使用.阳离子脂质体作为新型基因与药物传递系统,近年来备受众多研究学者的青睐.最重要的是阳离子脂质体共载基因与化疗药物进行联合治疗具有良好的协同增效作用,主要是外源基因可以沉默相关基因的表达,且提高胞内化疗药物浓度.该方法可以减少药物的使用剂量以达到相同治疗效果.从某种程度上克服了传统化疗的主要限制.因此在未来癌症治疗中,共载基因与药物联合治疗递送体系将发挥更大作用,特别有望用于多药耐药肿瘤中的临床治疗.

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