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Advance in the study of targeting delivery system for siRNA mediated by aptamers

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Author:: No author available

Journal Title:: Acta Pharmaceutica Sinica

Issue:: 7

DOI:: No doi available

Key Word:: siRNA;适配子;靶向;药物递送

Abstract： RNA干扰技术(RNAi)作为一种新型的基因治疗技术已应用到许多疾病的体外研究中,但靶向递送技术仍是目前制约小干扰RNA(siRNA)药物成功进入临床的关键技术问题.寡核苷酸适配子具有高亲和性、高靶向性,成为递送siRNA的重要手段.本文综述了 siRNA体内递送的主要障碍,以及近年来适配子介导的siRNA靶向递送系统的最新研究进展.

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