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Advances in the study of derivatization of ginsenosides and their anti-tumor structure-activity relationship

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Author:: No author available

Journal Title:: Acta Pharmaceutica Sinica

Issue:: 7

DOI:: No doi available

Key Word:: 人参皂苷;衍生化;抗肿瘤活性;构效关系

Abstract：人参皂苷为三萜类化合物,其某些衍生物在抑制肿瘤细胞生长或转移、诱导肿瘤细胞凋亡和分化、逆转肿瘤多药耐药等药理活性方面强于人参中主要的原生皂苷,人参皂苷衍生物作为抗肿瘤药物具有研究价值和开发前景.本文对人参皂苷衍生化的方法、主要衍生物及其抗肿瘤构效关系进行归纳总结,为新的抗肿瘤药物研究和开发提供参考.

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