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Synthesis of benzothiazole derivatives and their binding characteristics with β-amyloid
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- Author:
- No author available
- Journal Title:
- Acta Pharmaceutica Sinica
- Issue:
- 5
- DOI:
- No doi available
- Key Word:
- 阿尔茨海默病;β-淀粉样蛋白;PIB;希夫碱;表面等离子共振
Abstract： 阿尔茨海默病(Alzheimer's disease,AD)是一种神经退行性疾病.随着人口老龄化,发病率逐年增高,不仅严重危害着老年人的健康,而且给家庭、社会带来了巨大的经济和人力负担.在我国1.3亿老年人中,痴呆患者600～700万人,发病率在5％以上,约占世界总病例的1/4,成为世界老年痴呆症第一大国[1].AD常隐匿起病,逐渐出现记忆力减退、认知功能障碍、精神行为异常等症状,最终死于感染等严重并发症.病因是多源性的,在出现症状之前尚缺乏确诊手段,只能靠死后尸检[2].
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