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Comparison of the brain pharmacokinetics of nasal tetramethylpyrazine phosphate pH-sensitive in situ gel in normal rats and model rats
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- Author:
- No author available
- Journal Title:
- Acta Pharmaceutica Sinica
- Issue:
- 5
- DOI:
- No doi available
- Key Word:
- 磷酸川芎嗪;原位凝胶;脑部药动学
Abstract： 川芎嗪(tetramethylpyrazine,TMP)是从中药川芎的根茎中提取的生物碱单体,磷酸川芎嗪(tetramethylpyrazine phosphate,TMPP)具有扩张血管、增加冠脉及脑血流、抑制血小板聚集和降低血小板活性等作用[1,2],临床上广泛用于治疗闭塞性血管疾病、脑血栓形成、脉管炎、冠心病、心绞痛、缺血性脑血管疾病.
- [1]刘宏伟,晏亦林,周莉玲.磷酸川芎嗪鼻用pH敏感型原位凝胶的处方优化[J].2010,(9).
- [2]Longa E. Z.,Weinstein P. R.,Carlson S.,etc.Reversible middle cerebral artery occlusion without craniectomy in rats[J].1989.
- [3]Akihiro Ohta,Hiromitsu Takahashi,Naoomi Miyata,etc.Anti-Platelet Aggregation Activity of Some Pyrazines[J].1997,20(10).
- [4]Y K, Abu-Osba.Treatment of persistent pulmonary hypertension of the newborn: update.[J].1991,66.