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Thoughts and exploration on pharmacokinetic study of herbal medicines based on metabonomics and complex network

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Author:: No author available

Journal Title:: Acta Pharmaceutica Sinica

Issue:: 5

DOI:: No doi available

Key Word:: 中药药代动力学;代谢组学;复杂网络

Abstract：药物研发模式的转变推动了药物评价技术体系的革新.中药药代动力学研究是中药现代化研究的重要组成部分,对于创新中药及现代中药复方研发具有重要意义.中药药代动力学理论近些年虽然取得了进步,但目前尚缺乏符合中药自身特征的药代动力学研究与评价技术体系.本文扼要介绍了中药药代动力学的研究现状、代谢组学及复杂网络理论,并在此基础上提出应用代谢组学和复杂网络方法来研究多组分药代动力学(网络药动学)的设想,以期揭示中药药效物质基础和作用机制.

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