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Effect of ferulic acid on learning and memory impairments of vascular dementia rats and its mechanism of action
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- Author:
- No author available
- Journal Title:
- Acta Pharmaceutica Sinica
- Issue:
- 2
- DOI:
- No doi available
- Key Word:
- 阿魏酸;血管性痴呆;乙酰胆碱酯酶;兴奋性氨基酸;抗氧化作用
Abstract： 血管性痴呆(vascular dementia,VD)是一种严重威胁老年人生命健康的神经退行性疾病,随着人口的老龄化,VD发病率逐年上升,寻找安全有效的抗VD药物已成为药物研究的热点[1,2].近年来,中医药以活血化瘀法治疗VD取得了较大进展[3-5].川芎是一种典型的活血化瘀中药,始载于《神农本草经》,具有活血行气、祛风止痛的功效,广泛用于VD的治疗[6-9];其活血化瘀主要成分阿魏酸(ferulic acid,FA)具有抗血小板聚集、抗氧化、抗血栓、扩血管等药理作用[10,11],但阿魏酸对VD的预防和治疗作用及其机制目前尚未见报道.
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