You Position: Home > Paper

UPLC-TOF/MS based chemical profiling approach to evaluate toxicity-attenuated chemical composition in combination of ginseng and Radix Aconiti Praeparata

( views:15, downloads:0 )
Author:
No author available
Journal Title:
Acta Pharmaceutica Sinica
Issue:
12
DOI:
No doi available
Key Word:
人参;附子;配伍

Abstract: 利用超高效液相色谱-飞行时间质谱联用技术(UPLC-TOF/MS)分析人参附子药对配伍减毒的物质基础,从化学成分层次阐释其配伍减毒机制.基于UPLC-TOF/MS建立人参附子药对配伍后生物碱类成分的化学指纹图谱,通过主成分分析法和正交偏最小二乘判别法分析药对配伍在合煎过程中的生物碱类成分的含量变化,找出差异变化显著的化学成分.结果表明,正离子模式时人参附子药对合煎液中次乌头碱、去氧乌头碱的含量明显降低,而苯甲酰中乌头原碱、苯甲酰次乌头原碱和去乙酸中乌头原碱等含量升高.人参附子药对配伍应用时双酯型二萜生物碱的含量明显降低,而单酯型二萜生物碱的含量明显升高,这可能是人参附子药对配伍减毒作用的物质基础.

WanfangData CO.,Ltd All Rights Reserved
About WanfangData | Contact US
Healthcare Department, Fuxing Road NO.15, Haidian District Beijing, 100038 P.R.China
Tel:+86-010-58882616 Fax:+86-010-58882615 Email:yiyao@wanfangdata.com.cn