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Research progress of zebrafish used in drug metabolism

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Author:: No author available

Journal Title:: Acta Pharmaceutica Sinica

Issue:: 9

DOI:: No doi available

Key Word:: 斑马鱼;细胞色素P450酶;核受体

Abstract：斑马鱼作为模式生物已经被广泛地用于药物研发的各个过程中.斑马鱼中有细胞色素P450酶(cytochrome P450,CYP450)、尿苷二磷酸葡萄糖基转移酶(uridine 5’-diphospho-glucuronosyltrans ferase,UGT)等多种药物代谢酶和核受体如孕烷X受体(pregnane X receptor,PXR)、芳香烃受体(aryl hydrocarbon receptor,AHR)等的表达.本文综述了斑马鱼中主要的药物代谢酶和核受体的表达情况,以及在药物等外源物代谢研究中的进展.

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