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Advances in parallel artificial membrane permeability assay and its applications

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Author:: No author available

Journal Title:: ACTA PHARMACEUTICA SINICA

Issue:: 8

DOI:: No doi available

Key Word:: 平行人工膜渗透模型;磷脂;被动扩散

Abstract：随着新药研发水平的提高,每类药物的候选化合物增多,研究工作量明显增加,对化合物进行快速筛选的方法已经成为研究的重点之一.平行人工膜渗透模型(PAMPPA)作为药物筛选的有力工具,已用于药物研究中.该模型主要以人工磷脂作为生物膜来模拟药物跨膜的屏障,用于药物的膜渗透研究.本文介绍了平行人工膜渗透模型的建立、特点和研究进展,概述了利用PAMPA进行药物筛选等方面内容.通过调整人工磷脂膜的配比,PAMPA能够作为肠道、血脑屏障和皮肤吸收等体外模型.作为药物被动转运模型,PAMPA能够对药物进行高通量快速筛选,具有成本低、灵活、用药量少和重现性好等特点.

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