You Position: Home > Paper
Thermosensitive in situ gel of boanmycin hydrochloride for injection
( views:18, downloads:0 )
- Author:
- No author available
- Journal Title:
- ACTA PHARMACEUTICA SINICA
- Issue:
- 6
- DOI:
- No doi available
- Key Word:
- 盐酸博安霉素;温度敏感原位凝胶;胶凝温度;流变学;质构特性;药代动力学
Abstract： 本文以泊洛沙姆F127为主要基质材料,复合使用泊洛沙姆F68和高分子材料羟丙基甲基纤维素K4M,制备盐酸博安霉素注射用温度敏感原位凝胶.对凝胶的胶凝温度、流变学、质构特性、电镜结构和体外释放等性能进行了研究,并考察了该制剂在大鼠体内的药代动力学.结果表明,制备的盐酸博安霉素注射用温度敏感原位凝胶在常温下为流动的液体,在人体温度下能够发生相转变,成为具有一定胶凝强度的半固体,方便注射给药,胶凝后呈现三维网状空间结构,药物的扩散和凝胶材料的溶蚀为控制药物释放的主要因素.该制剂具有明显的缓释作用,在大鼠体内可以持续释放48 h以上.
- [1]LI Xin-yu,李欣宇,朱照静,等.地塞米松磷酸钠温度敏感原位凝胶的特性研究[J].2008,(2).
- [2]邓丽娟,李桂玲,丁维明,等.喷昔洛韦眼用温度敏感原位凝胶的制备及质量控制[J].2010,(6).
- [3]邓丽娟,李桂玲,李眉.注射用原位凝胶的研究进展[J].2009,(9).
- [4]马金兰,冯奉仪,周立强,等.博安霉素药动学研究及临床评价[J].2005,(17).
- [5]李桂玲,李眉.喷昔洛韦眼用温度敏感原位凝胶的制备及评价[J].2007,(2).
- [6]刘秀均,李毅,甄永苏.博安霉素对小鼠结肠癌及其肝转移的抑制作用[J].2001,(1).
- [7]Zhang Q,Zhang X,Wang XQ,etc.Controlled delivery of recombinant hirudin based on thermo-sensitive Pluronic (R) F127 hydrogel for subcutaneous administration: In vitro and in vivo characterization[J].2007,117(3).
- [8]Choi HG,Choi JS,Quan QZ,etc.Effect of sodium chloride on the gelation temperature, gel strength and bioadhesive force of poloxamer gels containing diclofenac sodium.[J].2001,226(1).
- [9]马金兰,汤致强,周立强,等.盐酸博安霉素临床药代动力学研究[J].1995,(4).
- [10]Lee YH,Park TG,Chung HJ.Thermo-sensitive and biodegradable hydrogels based on stereocomplexed Pluronic multi-block copolymers for controlled protein delivery[J].2008,127(1).
- [11]Ricci EJ,Lunardi LO,Marchetti JM,etc.Sustained release of lidocaine from Poloxamer 407 gels.[J].2005,288(2).
- [12]Emilie, Patois,Suzanne, Osorio-da Cruz,Jean-Christophe, Tille,etc.Novel thermosensitive chitosan hydrogels: in vivo evaluation.[J].2009,91(2).