Paper - WANFANG MED ONLINE

You Position: Home > Paper

Development of targeting thermosensitive liposomes for tumor treatment

( views:19, downloads:0 )

Author:: No author available

Journal Title:: ACTA PHARMACEUTICA SINICA

Issue:: 5

DOI:: No doi available

Key Word:: 脂质体;靶向给药;抗肿瘤药物;触发释放

Abstract：脂质体具有靶向传递药物进入肿瘤部位的优势,被广泛用于肿瘤的临床治疗,但是靶向传递并不能保证药物在肿瘤部位被生物利用.为了解决此问题,热敏靶向脂质体(TTL)已经成为目前的研究热点.TTL既能提高药物在肿瘤部位的浓度,又能在加热条件下触发释放所载药物,从而显著改善所载药物的抗肿瘤效果.本文主要综述了近年来该领域的研究进展.

Reference

[1]Wasan EK,Bally MB,Banno B,etc.The functional roles of poly(ethylene glycol)-lipid and lysolipid in the drug retention and release from lysolipid-containing thermosensitive liposomes in vitro and in vivo.[J].2010,99(5).
[2]Schipper D,Djanashvili K,ten Hagen TL,etc.Development of a liposomal delivery system for temperature-triggered release of a tumor targeting agent, Ln(III)-DOTA-phenylboronate.[J].2011,19(3).
[3]Zhao Y,Yarmolenko PS,Yuan F,etc.Comparative effects of thermosensitive doxorubicin-containing liposomes and hyperthermia in human and murine tumours.[J].2010,26(5).
[4]Woo J,Wasan E,Chiu GN,etc.Use of a passive equilibration methodology to encapsulate cisplatin into preformed thermosensitive liposomes.[J].2008,349(1).
[5]Needham D,Mills JK.Lysolipid incorporation in dipalmitoylphosphatidylcholine bilayer membranes enhances the ion permeability and drug release rates at the membrane phase transition[J].2005,1716(2).
[6]Harrington KJ,Lewanski CR,Northcote AD,etc.Phase I-II study of pegylated liposomal cisplatin (SPI-077) in patients with inoperable head and neck cancer.[J].2001,12(4).
[7]徐缓,王凯乾,黄微崴,等.聚乙二醇修饰脂质体的ABC现象研究进展[J].2010,(6).
[8]Li, L,ten Hagen, TLM,Schipper, D,etc.Triggered content release from optimized stealth thermosensitive liposomes using mild hyperthermia[J].2010,143(2).
[9]Katoh M,Morita K,Zywietz F,etc.Efficacy of doxorubicin thermosensitive liposomes (40 degrees C) and local hyperthermia on rat rhabdomyosarcoma.[J].2008,20(2).
[10]Lindner LH,Hossann M.Factors affecting drug release from liposomes.[J].2010,13(1).
[11]Hossann M,Teichert N,Wachholz K,etc.In vitro stability and content release properties of phosphatidylglyceroglycerol containing thermosensitive liposomes.[J].2007,1768(10).
[12]Lindner LH,Koning GA,Eggermont AM,etc.Hyperthermia and thermosensitive liposomes for improved delivery of chemotherapeutic drugs to solid tumors.[J].2010,27(8).
[13]Hossann M,Hiddemann W,Wachholz K,etc.Dual role of hexadecylphosphocholine (miltefosine) in thermosensitive liposomes: Active ingredient and mediator of drug release[J].2008,125(2).
[14]Yuan F,Krol A,Chen Q,etc.Tumor microvascular permeability is a key determinant for antivascular effects of doxorubicin encapsulated in a temperature sensitive liposome.[J].2008,24(6).
[15]Hossann, M.,Wang, T.,Wiggenhorn, M.,etc.Size of thermosensitive liposomes influences content release[J].2010,147(3).
[16]M S, Newman,G T, Colbern,P K, Working,etc.Comparative pharmacokinetics, tissue distribution, and therapeutic effectiveness of cisplatin encapsulated in long-circulating, pegylated liposomes (SPI-077) in tumor-bearing mice.[J].1999,43(1).
[17]Ozawa T,Aoshima S,Harada A,etc.Highly temperature-sensitive liposomes based on a thermosensitive block copolymer for tumor-specific chemotherapy.[J].2010,31(27).
[18]Mann K,Kullberg M,Owens JL.A two-component drug delivery system using Her-2-targeting thermosensitive liposomes.[J].2009,17(2).
[19]Barenholz Y,Gabizon A,Shmeeda H.Pharmacokinetics of pegylated liposomal Doxorubicin: review of animal and human studies.[J].2003,42(5).
[20]Olga Mykhaylyk,Jyotsnendu Giri,Finn Rieken,etc.Targeted temperature sensitive magnetic liposomes for thermo-chemotherapy[J].2010,142(1).
[21]Wu C,Yang Y,Zhang FC,etc.Epirubicin-encapsulated long-circulating thermosensitive liposome improves pharmacokinetics and antitumor therapeutic efficacy in animals.[J].2011,21(3).