Paper - WANFANG MED ONLINE

You Position: Home > Paper

Research progress of polyamidoamine dendrimer in targeting drug delivery system

( views:23, downloads:0 )

Author:: No author available

Journal Title:: ACTA PHARMACEUTICA SINICA

Issue:: 5

DOI:: No doi available

Key Word:: 聚酰胺-胺;树状大分子;靶向给药系统;药物载体;配基

Abstract：靶向给药系统(targeting drug delivery system,TDDS)能够选择性作用于病变部位,控制药物的分布与释放,提高药效和降低毒副作用,已成为癌症治疗领域的研究热点之一.聚酰胺-胺树状大分子(polyamidoaminedendrimer,PAMAMD)是一种新近发展起来的纳米级药物载体,多分枝、单分散性、三维结构和主-客体包裹能力使其可作为药物基因载体和影像试剂.PAMAMD丰富的末端功能团能同时连接各种具有特异选择性的靶向配基,再通过包裹作用或化学偶联作用将药物或治疗基因载入,最后将药物和治疗基因带到病变部位释放从而实现靶向治疗.这种以PAMAMD为基础制备的纳米靶向给药系统具有较小的粒径,强的高通透高滞留(enhancedpermeability and retention,EPR)效应和低毒性等特点.本文概述了各种靶向配基修饰的PAMAMD的应用研究进展,并展望了今后的研究方向.

Reference

[1]李瑞,张军霞,石磊,等.新型超微载体FA-PAMAM介导hTERT-siRNA对人脑胶质瘤细胞系U251抑制作用的体外研究[J].2008,(4).
[2]温玉婷,潘仕荣,郭振寰,等.组氨酸修饰聚酰胺-胺型树状高分子提高血清中基因转染效率的研究[J].2010,(1).
[3]孔淑仪,唐国涛,裴元英,等.聚乙二醇修饰的聚酰胺-胺-甲氨蝶呤分子复合物的制备及体外释药研究[J].2008,(14).
[4]Palakurthi S,Yellepeddi VK,Kumar A.Biotinylated poly(amido)amine (PAMAM) dendrimers as carriers for drug delivery to ovarian cancer cells in vitro.[J].2009,29(8).
[5]Cheng Y,Ma M,Xu Z,etc.Dendrimers as drug carriers: applications in different routes of drug administration.[J].2008,97(1).
[6]Huang R,Ke W,Shao K.Gene delivery targeted to the brain using an Angiopep-conjugated polyethyleneglycol-modified polyamidoamine dendrimer.[J].2009,30(36).
[7]Chandrasekar D,Sistla R,Khar RK,etc.The development of folate-PAMAM dendrimer conjugates for targeted delivery of anti-arthritic drugs and their pharmacokinetics and biodistribution in arthritic rats[J].2007,28(26).
[8]Ke W,Jiang C,Liu S,etc.Targeted delivery of chlorotoxin-modified DNA-loaded nanoparticles to glioma via intravenous administration.[J].2011,32(9).
[9]Gillies ER,Frechet JM.Dendrimers and dendritic polymers in drug delivery.[J].2005,10(1).
[10]陆珺珺,吴正红,平其能.聚酰胺-胺PAMAM树状聚合物对灯盏花素的溶解性及其药代动力学的影响[J].2009,(2).
[11]唐杨,马丽芳,郭丽,等.聚酰胺-胺树状大分子作为药物载体的体外增溶、缓释试验[J].2009,(1).
[12]Choi Y,Kotlyar A,Islam MT,etc.Synthesis and functional evaluation of DNA-assembled polyamidoamine dendrimer clusters for cancer cell-specific targeting[J].2005,12(1).
[13]Jeong Y,Nam HY,Choi WH,etc.Evaluation of generations 2, 3 and 4 arginine modified PAMAM dendrimers for gene delivery.[J].2008,363(1).
[14]Yang WL,Jiang C,Huang RQ,etc.Gene delivery into brain capillary endothelial cells using Antp-modified DNA-loaded nanoparticles[J].2006,54(9).
[15]DeLong R,Fisher MH,Kang H,etc.Tat-conjugated PAMAM dendrimers as delivery agents for antisense and siRNA oligonucleotides.[J].2005,22(12).
[16]Andrzej Myc,Thommey Thomas,Chandan B.Mehta,etc.PAMAM Dendrimer-Based Multifunctional Conjugate for Cancer Therapy:Synthesis, Characterization, and Functionality[J].2006,7(2).
[17]E C, Wiener,S, Konda,A, Shadron,etc.Targeting dendrimer-chelates to tumors and tumor cells expressing the high-affinity folate receptor.[J].1997,32.
[18]Yadav AK,Bhadra D,Bhadra S,etc.Glycodendrimeric nanoparticulate carriers of primaquine phosphate for liver targeting.[J].2005,295(1).
[19]Mazur J,Szwedzka M,Zaborski M,etc.Interaction between PAMAM 4.5 dendrimer, cadmium and bovine serum albumin: A study using equilibrium dialysis, isothermal titration calorimetry, zeta-potential and fluorescence[J].2007,58(2).
[20]孙玉,于菲,孙柏旺.靶向癌症治疗试剂--抗体-药物偶联物[J].2009,(9).
[21]Cheng Y,Wang X,Wen LP,etc.Targeting cancer cells with biotin-dendrimer conjugates.[J].2009,44(2).
[22]Jennifer L.Peters,Rameshwer Shukla,Thommey P.Thomas.HER2 Specific Tumor Targeting with Dendrimer Conjugated Anti-HER2 mAb[J].2006,17(5).
[23]Low PS,Henne WA,Doorneweerd DD.Discovery and development of folic-acid-based receptor targeting for Imaging and therapy of cancer and inflammatory diseases[J].2008,41(1).
[24]Qu H,Fang Y,Ma M,etc.Polyamidoamine (PAMAM) dendrimers as biocompatible carriers of quinolone antimicrobials: an in vitro study.[J].2007,42(7).
[25]Svenson S.Dendrimers as versatile platform in drug delivery applications.[J].2009,71(3).
[26]Zhu S,Tang,Hong M.Partly PEGylated polyamidoamine dendrimer for tumor-selective targeting of doxorubicin: the effects of PEGylation degree and drug conjugation style.[J].2010,31(6).
[27]Meng M,Li X,Wang P,etc.Generation 4 polyamidoamine dendrimers is a novel candidate of nano-carrier for gene delivery agents in breast cancer treatment.[J].2010,298(1).
[28]Thomas TP,Kotlyar A,Myc A,etc.Tumor angiogenic vasculature targeting with PAMAM dendrimer-RGD conjugates[J].2005,0(46).
[29]James Beals,Anil K.Patri,James R.Baker,etc.Synthesis and in Vitro Testing of J591 Antibody-Dendrimer Conjugates for Targeted Prostate Cancer Therapy[J].2004,15(6).
[30]Akita H,Inoue K,Maeda A,etc.Pharmacokinetics and brain uptake of lactoferrin in rats[J].2006,78(8).
[31]Wolinsky JB,Grinstaff MW.Therapeutic and diagnostic applications of dendrimers for cancer treatment.[J].2008,60(9).
[32]Pan, S.,Wang, Y.A.,Chang, Y.,etc.Synthesis and grafting of folate-PEG-PAMAM conjugates onto quantum dots for selective targeting of folate-receptor-positive tumor cells[J].2010,350(1).
[33]Abhay Asthana,Prateek Singh,Umesh Gupta.Folate and Folate-PEG-PAMAM Dendrimers: Synthesis, Characterization, and Targeted Anticancer Drug Delivery Potential in Tumor Bearing Mice[J].2008,19(11).
[34]Yang YY,Wiradharma N,Tong YW.Self-assembled oligopeptide nanostructures for co-delivery of drug and gene with synergistic therapeutic effect.[J].2009,30(17).
[35]Kurtoglu YE,Mishra MK,Kannan.Drug release characteristics of PAMAM dendrimer-drug conjugates with different linkers.[J].2010,384(1).
[36]Ke WL,Qu YH,Jiang C,etc.Efficient gene delivery targeted to the brain using a transferrin-conjugated polyethyleneglycol-modified polyamidoamine dendrimer[J].2007,21(4).
[37]Kim, TI,Bai, CZ,Nam, K,etc.Comparison between arginine conjugated PAMAM dendrimers with structural diversity for gene delivery systems[J].2009,136(2).
[38]Kim HJ,Choi JS,Park JS,etc.Biodegradable PAMAM ester for enhanced transfection efficiency with low cytotoxicity.[J].2009,30(4).
[39]S S, Chang,D S, O'Keefe,D J, Bacich,etc.Prostate-specific membrane antigen is produced in tumor-associated neovasculature.[J].1999,5.
[40]Ying XY,Zou JH,Jin Y,etc.PAMAM-triamcinolone acetonide conjugate as a nucleus-targeting gene carrier for enhanced transfer activity.[J].2009,30(30).
[41]Ke WL,Jiang C,Pei YY,etc.The use of lactoferrin as a ligand for targeting the polyamidoamine-based gene delivery system to the brain[J].2008,29(2).
[42]孔淑仪,唐国涛,裴元英,等.PAMAM-PEG/甲氨蝶呤复合物在正常及荷瘤鼠体内的药动学和抗肿瘤活性[J].2009,(1).
[43]Oliveira JM,Kotobuki N,Tadokoro M,etc.Ex vivo culturing of stromal cells with dexamethasone-loaded carboxymethylchitosan/poly(amidoamine) dendrimer nanoparticles promotes ectopic bone formation.[J].2010,46(5).
[44]Tomalia DA,Huang BH.Dendronization of gold and CdSe/cdS (core-shell) quantum functionalized dendrons dots with tomalia type, thiol core, poly(amidoamine) (PAMAM) dendrons[J].2005,111(4).
[45]Duncan R,Izzo L.Dendrimer biocompatibility and toxicity.[J].2005,57(15).
[46]Jay ant Khandare,Tamara Minko.Polymer-drug conjugates: Progress in polymeric prodrugs[J].2006,31(4).
[47]Kumar A,Yellepeddi VK,Davies GE,etc.Enhanced gene transfection efficiency by polyamidoamine (PAMAM) dendrimers modified with ornithine residues.[J].2010,392(1).
[48]He H,Li Y,Jia XR,etc.PEGylated Poly(amidoamine) dendrimer-based dual-targeting carrier for treating brain tumors.[J].2011,32(2).
[49]G. Moldenhauer,M. Eisenhut,C. Wangler.Antibody-Dendrimer Conjugates: The Number, Not the Size of the Dendrimers, Determines the Immunoreactivity[J].2008,19(4).
[50]Li MH,Kotlyar A,Choi SK,etc.Design of riboflavin-presenting PAMAM dendrimers as a new nanoplatform for cancer-targeted delivery.[J].2010,20(17).
[51]Ratnam M,Salazar MD.The folate receptor: what does it promise in tissue-targeted therapeutics?[J].2007,26(1).