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Application of small molecule compounds in inducing differentiation of stem cells
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- Author:
- No author available
- Journal Title:
- ACTA PHARMACEUTICA SINICA
- Issue:
- 2
- DOI:
- No doi available
- Key Word:
- 干细胞;小分子化合物;诱导;分化
Abstract： 随着干细胞和再生医学(利用干细胞治疗各种疾病)研究的进步,人类在诱导干细胞分化的技术领域也取得了显著进展.其中化学生物学的发展为干细胞研究提供了多种多样的生物活性小分子,基于其自身的优势,小分子正越来越多地应用于干细胞的研究.本文综述了天然和合成的小分子化合物针对性的诱导干细胞分化方面的研究.
- [1]林绿标,章翔,姬西团,等.外源性一氧化氮对神经干细胞分化的促进作用[J].2004,(4).
- [2]Liu, R.-H.,Tan, Y.-X.,Li, H.-L.,etc.Antitumor and antiplatelet activity of alkaloids from Veratrum dahuricum[J].2010,24(6).
- [3]Ding S,Chen SB,Hilcove S.Exploring stem cell biology with small molecules[J].2006,2(1).
- [4]Skoudy A,Rovira M,Savatier P,etc.Transforming growth factor (TGF)beta, fibroblast growth factor (FGF) and retinoid signalling pathways promote pancreatic exocrine gene expression in mouse embryonic stem cells[J].2004,379(Pt.3).
- [5]J, Taipale,J K, Chen,M K, Cooper,etc.Effects of oncogenic mutations in Smoothened and Patched can be reversed by cyclopamine.[J].2000,406(6799).
- [6]Graichen R,Norfiza S,Davidson BP,etc.Enhanced cardiomyogenesis of human embryonic stem cells by a small molecular inhibitor of p38 MAPK.[J].2008,76(4).
- [7]Wurdak H,Wang J,Peters EC,etc.A small molecule primes embryonic stem cells for differentiation.[J].2009,4(5).
- [8]Sato F,Sasaki K,Shirasawa S,etc.Combination of small molecules enhances differentiation of mouse embryonic stem cells into intermediate mesoderm through BMP7-positive cells.[J].2010,393(4).
- [9]Hee Jung Jung,Sung Wook Kwon,Na Ri Kim,etc.Discovery of a New and Efficient Small Molecule for Neuronal Differentiation from Mesenchymal Stem Cell[J].2009,52(24).
- [10]Evelyn CR,Wade SM,Wang Q,etc.CCG-1423: a small-molecule inhibitor of RhoA transcriptional signaling.[J].2007,6(8).
- [11]Melton DA,Kim SK.Pancreas development is promoted by cyclopamine, a hedgehog signaling inhibitor.[J].1998,95(22).
- [12]Ding S,Brinker A,Schultz PG,etc.Synthetic small molecules that control stem cell fate.[J].2003,100(13).
- [13]Tang J,Yan SK,Shen YH,etc.Antitumor activity of extracts and compounds from the rhizomes of Veratrum dahuricum[J].2008,22(8).
- [14]Chen, S,Borowiak, M,Fox, JL,etc.A small molecule that directs differentiation of human ESCs into the pancreatic lineage[J].2009,5(4).
- [15]Yuichi Hori,Bernette C. Tsai,Jeremy J. Heit,etc.Growth inhibitors promote differentiation of jnsulin-producing tissue from embryonic stem cells[J].2002,99(25).
- [16]Schreiber SL,Melton DA,Fox JL,etc.Small molecules efficiently direct endodermal differentiation of mouse and human embryonic stem cells.[J].2009,4(4).
- [17]Yao M.,Huettner JE.,Gottlieb DI.,etc.Embryonic Stem Cells Express Neuronal Properties in Vitro[J].1995,168(2).