You Position: Home > Paper

Synthesis and antiproliferative activities of novel 5'-Schiff-base group substituted psoralen derivatives

( views:19, downloads:0 )
Author:
No author available
Journal Title:
ACTA PHARMACEUTICA SINICA
Issue:
1
DOI:
No doi available
Key Word:
补骨脂素衍生物;席夫碱基团;合成;抗增殖活性;psoralen derivative;Schiff-base group;synthesis;antiproliferative activity

Abstract: It was found that psoralen derivative could perform a Friedel-Crafts acylation smoothly with acetic anhydride to give 5'-acetylpsoralen in a 73% yield. In the presence of boron trifluoride etherate, 5'-acetylpsoralen reacted with both aromatic amines and aliphatic amine smoothly to afford 5'-Schiff-base group substituted psoralen derivatives in 72%~92% yields. The novel synthetic method has the advantages of cheap materials, mild reaction conditions, good yields and high regioselectivity in the Friedel-Crafts acylation. Cell viability assay by MTT demonstrates that some of the psoralen derivatives 6 have antiproliferative activities.

WanfangData CO.,Ltd All Rights Reserved
About WanfangData | Contact US
Healthcare Department, Fuxing Road NO.15, Haidian District Beijing, 100038 P.R.China
Tel:+86-010-58882616 Fax:+86-010-58882615 Email:yiyao@wanfangdata.com.cn