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Network pharmacology: new guidelines for drug discovery

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Author:: No author available

Journal Title:: ACTA PHARMACEUTICA SINICA

Issue:: 12

DOI:: No doi available

Key Word:: 疾病-药物网络;网络药理学;网络计算方法;药物发现

Abstract：新药研发是医药产业发展的核心驱动力,也是社会发展的重要需求,但近年来,随着对药物研发要求的不断提高,新药研发正面临着巨大困难,单靶点高选择性的新药研发思想遇到了挑战,已经显示出发展的局限性.网络药理学是近年来在单靶点药物研究的基础上提出的新药发现新策略.本文围绕网络药理学的形成基础和目前研究现状,探讨网络药理学发展的方向和应用前景,同时分析网络药理学的局限性和存在的问题,并通过与传统中医药学理论和中药复方有效成分组学的思想相比较,探讨网络药理学在新药研发中的应用.

Reference

[1]王月华,杜冠华.复方小续命汤抗AD有效成分组研究[J].2005,(9).
[2]William C.S. Cho.Proteomics Technologies and Challenges[J].2007,(2).
[3]杜冠华,王月华,张冉,等.多成分多靶点是对中药作用机制的表面认识[J].2009,(4).
[4]杜冠华.中药复方有效成分组学研究[J].2002,(11).
[5]张冉,戴瑛,程新锐,等.消栓通络方有效成分组抗血栓作用及其机制研究[J].2006,(10).
[6]潘家祜.基于网络药理学的药物研发新模式[J].2009,(10).
[7]Keith CT,Borisy AA,Stockwell BR.Multicomponent therapeutics for networked systems.[J].2005,4(1).
[8]Patra, Jagdish C.,Li, Yongjin.Genome-wide inferring gene-phenotype relationship by walking on the heterogeneous network[J].2010,26(9).
[9]Hajduk,P.J.,Metz,J.T..Rational approaches to targeted polypharmacology: Creating and navigating protein-ligand interaction networks[J].2010,14(4).
[10]Keith CT,Lehar J,Zimmermann GR.Multi-target therapeutics: when the whole is greater than the sum of the parts.[J].2007,12(1).
[11]Katz JN,Solomon DH,Hawker GA.The patient's perspective on the recall of Vioxx.[J].2006,33(6).
[12]L'Allier PL,McMurray JJ,Klug E,etc.Effects of succinobucol (AGI-1067) after an acute coronary syndrome: a randomised, double-blind, placebo-controlled trial.[J].2008,371(9626).
[13]Oron, Vanunu,Oded, Magger,Eytan, Ruppin,etc.Associating genes and protein complexes with disease via network propagation.[J].2010,6(1).
[14]Vidal M,Barabasi AL,Yildirim MA,etc.Drug-target network.[J].2007,25(10).
[15]Csermely P,Agoston V,Pongor S.The efficiency of multi-target drugs: the network approach might help drug design.[J].2005,26(4).
[16]Dove WF,Eppig JT,Duyk G,etc.The knockout mouse project[J].2004,36(9).
[17]Thomas D,Friboulet A.Systems biology - an interdisciplinary approach[J].2005,20(12).
[18]Goh KI,Cusick ME,Valle D,etc.The human disease network[J].2007,104(21).
[19]Ooi SL,Pan X,Irizarry RA,etc.Global synthetic-lethality analysis and yeast functional profiling[J].2006,22(1).
[20]Bryan L Roth,Douglas J. Sheffler,Wesley K. Kroeze.Magic shotguns versus magic bullets: selectively non-selective drugs for mood disorders and schizophrenia[J].2004,3(4).
[21]Chyau, J..Casting a global safety net - a framework for food safety in the age of globalization.[J].2009,64(2).
[22]Manolis AS,Flordellis CS,Karabinis A,etc.Rethinking target discovery in polygenic diseases.[J].2006,6(16).
[23]Guri, Giaever,Angela M, Chu,Li, Ni,etc.Functional profiling of the Saccharomyces cerevisiae genome.[J].2002,418(6896).
[24]Hopkins AL.Network pharmacology: the next paradigm in drug discovery[J].2008,4(11).
[25]Hopkins AL,Overington JP,Mason JS.Can we rationally design promiscuous drugs?[J].2006,16(1).
[26]Brian P, Zambrowicz,Arthur T, Sands.Knockouts model the 100 best-selling drugs--will they model the next 100?[J].2003,2(1).
[27].Human host factors required for influenza virus replication[J].2010,463(Feb.11 TN.7282).
[28]Simon K, Mencher,Long G, Wang.Promiscuous drugs compared to selective drugs (promiscuity can be a virtue).[J].2005,5.
[29]Giordano S,Petrelli A.From single- to multi-target drugs in cancer therapy: when aspecificity becomes an advantage.[J].2008,15(5).
[30]Winzeler E. A..Functional Characterization of the S. cerevisiae Genome by Gene Deletion and Parallel Analysis[J].1999.
[31]Albert C, Yan,Kara N, Smolinski.Melanocytic nevi: challenging clinical situations in pediatric dermatology.[J].2005,21.
[32]Robin P, Dullaart,Anneke C Muller, Kobold,Arie, van Tol.Torcetrapib and coronary events.[J].2008,358(17).
[33]Zambrowicz BP,Turner CA,Sands AT.Predicting drug efficacy: knockouts model pipeline drugs of the pharmaceutical industry.[J].2003,3(5).
[34]Hughes,B..2008 FDA drug approvals[J].2009,8(2).
[35]Nussinov R,Keskin O,Ma B,etc.Towards drugs targeting multiple proteins in a systems biology approach.[J].2007,7(10).
[36]Mark R. Dyer,Dalia Cohen,Paul L. Herrling.Functional genomics: from genes to new therapies[J].1999,4(3).
[37]Xuebing, Wu,Rui, Jiang,Michael Q, Zhang,etc.Network-based global inference of human disease genes.[J].2008,4.