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The function of protein kinase C in myocardial fibrosis

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Author:: No author available

Journal Title:: ACTA PHARMACEUTICA SINICA

Issue:: 12

DOI:: No doi available

Key Word:: 蛋白激酶C;心肌成纤维细胞;心肌纤维化;心肌重塑;基质金属蛋白酶

Abstract：心肌纤维化是多种心脏疾病发展的共同结果,心肌成纤维细胞的增殖导致细胞外基质蛋白代谢紊乱,引起心肌重塑,最终导致恶性心律失常、心功能衰竭、甚至心脏性猝死的发生.有效地抑制心肌重塑可预防猝死的发生.明确蛋白激酶C(protein kinase C,PKC)对心肌纤维化的调控机制,可能为逆转心肌重塑提供新的治疗靶点.

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