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Advances in the study of structural modifications and biological activities of betulinic acids

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Author:: No author available

Journal Title:: ACTA PHARMACEUTICA SINICA

Issue:: 11

DOI:: No doi available

Key Word:: 白桦酸;23-羟基白桦酸;白桦素;结构修饰;抗HIV活性;抗肿瘤活性

Abstract：白桦酸类化合物属于羽扇豆烷型五环三萜化合物,主要分布在桦木科植物中,其良好的抗HIV、抗肿瘤活性正受到越来越多的关注.天然存在的白桦酸类化合物主要有白桦酸、23-羟基白桦酸及白桦素等.文献报道了不同白桦酸类化合物的结构修饰研究,并获得了一些具有较强生物活性的衍生物.本文主要对白桦酸类化合物的结构修饰及抗HIV、抗肿瘤作用研究进展进行综述.

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