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Recent advances in the study of new antifungal lead compounds

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Author:: No author available

Journal Title:: ACTA PHARMACEUTICA SINICA

Issue:: 8

DOI:: No doi available

Key Word:: 抗真菌;先导化合物;构效关系

Abstract：近年来,深部真菌感染的发生率和死亡率不断升高,研发全新结构类型和全新作用机制的抗真菌药物具有重要意义.本文综述了2007年至2009年新报道的抗真菌先导化合物,并对其化学结构、抗真菌活性和构效关系进行总结,为未来抗真菌新药研究提供指导信息.

Reference

[1]Isabelle E. Francois,Karin Thevissen,Klaartje Pellens.Design and Synthesis of a Series of Piperazine-1-carboxamidine Derivatives with Antifungal Activity Resulting from Accumulation of Endogenous Reactive Oxygen Species[J].2009,4(10).
[2]Ferreira D,Li XC,Jacob MR,etc.Synthesis, antifungal activity, and structure-activity relationships of coruscanone A analogues[J].2006,49(26).
[3]Yildiz S,Alp M,Goker H,etc.Synthesis and antiparasitic and antifungal evaluation of 2'-arylsubstituted-1H,1'H-(2,5')bisbenzimidazolyl-5-carboxamidines.[J].2009,44(5).
[4]M, Richardson,C, Lass-Fl?rl.Changing epidemiology of systemic fungal infections.[J].2008,14 Suppl 4.
[5]Emami S,Foroumadi A.3-Imidazolyl-Substituted Flavans as Potential Antifungal Agents: Synthesis, Stereochemical Properties, and Antifungal Activity.[J].2009,342(9).
[6]Annette W. Fothergill,Christina S. Stauffer,Pushpal Bhaket.Total Synthesis and Antifungal Activity of a Carbohydrate Ring-Expanded Pyranosyl Nucleoside Analogue of Nikkomycin B[J].2007,72(26).
[7]Hanadate T,Tomishima M,Shiraishi N,etc.FR290581, a novel sordarin derivative: synthesis and antifungal activity.[J].2009,19(5).
[8]Tapcov V,Birca M,Gulea A,etc.In vitro antileukemia, antibacterial and antifungal activities of some 3d metal complexes: chemical synthesis and structure - activity relationships.[J].2008,23(6).
[9]Frampton JE,Scott LJ.Posaconazole: a review of its use in the prophylaxis of invasive fungal infections.[J].2008,68(7).
[10]Ryu CK,Lee RY,Kim NY.Synthesis and antifungal activity of benzo(d)oxazole-4,7-diones.[J].2009,19(20).
[11]Frost S,Rogers TR.Newer antifungal agents for invasive fungal infections in patients with haematological malignancy.[J].2009,144(5).
[12]Ryu CK,Nho JH,Jeong SH,etc.Synthesis and antifungal activity of 1H-pyrrolo(3,2-g)quinoline-4,9-diones and 4,9-dioxo-4,9-dihydro-1H-benzo(f)indoles.[J].2009,19(1).
[13]Rezaei Z,Hossaini Z,Assadpour E,etc.Design, synthesis, and antifungal activity of triazole and benzotriazole derivatives.[J].2009,44(7).
[14]Ma MY,Nho JH,Ryu CK,etc.Synthesis and antifungal activity of 6-arylamino-phthalazine-5,8-diones and 6,7-bis(arylthio)-phthalazine-5,8-diones.[J].2007,17(9).
[15]Wong B,Yeo SF.Current status of nonculture methods for diagnosis of invasive fungal infections.[J].2002,15(3).
[16]Onnis V,Cocco MT,Meleddu R,etc.2-Acylhydrazino-5-arylpyrrole derivatives: synthesis and antifungal activity evaluation.[J].2009,44(3).
[17]De Sarro A,La Camera E,Fera MT.New triazoles and echinocandins: mode of action, in vitro activity and mechanisms of resistance.[J].2009,7(8).
[18]Yao B,Ji HT,Cao YB,etc.Synthesis and antifungal activities of novel 2-aminotetralin derivatives[J].2007,50(22).
[19]Gopalakrishnan M,Sureshkumar P,Thanusu J,etc.Synthesis, spectral analysis, antibacterial and antifungal activities of some 4,6-diaryl-4,5-dihydro-3-hydroxy-2(H)-indazole-a novel fused indazole derivative.[J].2008,23(6).
[20]Obando D,Pantarat N,Handke R.Synthesis, antifungal, haemolytic and cytotoxic activities of a series of bis(alkylpyridinium)alkanes.[J].2009,17(17).
[21]Groll AH,Tragiannidis A.Recent advances in antifungal prevention and treatment.[J].2009,46(3).
[22]Kully M,Khan JK,Daneshtalab M,etc.Synthesis of chlorogenic acid derivatives with promising antifungal activity.[J].2007,15(21).
[23]Kenéz,á.,Lestár,Z.,Lenkey,B.,etc.Synthesis and structure-activity relationship study of monotesone-A, an antifungal component of Monotes engleri[J].2008,22(5).
[24]Sangshetti JN,Nagawade RR,Shinde DB.Synthesis of novel 3-(1-(1-substituted piperidin-4-yl)-1H-1,2,3-triazol-4-yl)-1,2,4-oxadiazol-5(4H)-one as antifungal agents.[J].2009,19(13).
[25]Kauffman CA,Sobel JD,Fisher JF,etc.Clinical practice guidelines for the management of candidiasis: 2009 update by the Infectious Diseases Society of America.[J].2009,48(5).
[26]Perfect JR,Gibbs WJ,Drew RH.Liposomal amphotericin B: clinical experience and perspectives.[J].2005,3(2).
[27]Chen A,Sobel JD.Emerging azole antifungals.[J].2005,10(1).
[28]Ryu CK,Ma MY,Park RE,etc.Synthesis and antifungal activity of 1H-indole-4,7-diones.[J].2007,17(1).
[29]Bouet G,Belaid S,Benali-Baitich O,etc.Synthesis, characterization and antifungal activity of a series of manganese(II) and copper(II) complexes with ligands derived from reduced N, N '-O-phenylenebis(salicylideneimine)[J].2008,102(1).
[30]Saravanan G,Ingarsal N,Nagarajan S,etc.Synthesis, in vitro antibacterial and antifungal evaluations of 2-amino-4-(1-naphthyl)-6-arylpyrimidines.[J].2007,42(4).
[31]Fermeglia M,Vio L,Scialino G,etc.Synthesis, antifungal and antimycobacterial activities of new bis-imidazole derivatives, and prediction of their binding to P450(14DM) by molecular docking and MM/PBSA method.[J].2007,15(23).
[32]Denning D,Hope W,Walsh T.Laboratory diagnosis of invasive aspergillosis.[J].2005,5(10).
[33]Lasso M,Velez J,Lipka J,etc.Caspofungin for the treatment of less common forms of invasive candidiasis.[J].2007,60(2).
[34]Denning DW,Pasqualotto AC.New and emerging treatments for fungal infections.[J].2008,61(Suppl.1).
[35]Thomas J. Walsh.Treatment of Aspergillosis: Clinical Practice Guidelines of the Infectious Diseases Society of America[J].2008,46(3).