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G3BP: a promising target for cancer therapy

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Author:: No author available

Journal Title:: ACTA PHARMACEUTICA SINICA

Issue:: 8

DOI:: No doi available

Key Word:: G3BP;RasGAP;RNA代谢;抗肿瘤药物;肿瘤治疗

Abstract： G3BP(RasGAP SH3 domain binding protein)是一种RasGAP SH3结构域特异性结合蛋白,参与Ras下游信号通路,属于RNA结合蛋白家族.G3BP具有核酸内切酶、DNA解旋酶活性,能够诱导应急颗粒的形成,参与多种细胞生长、分化、凋亡和RNA代谢的信号通路.已经发现G3BP在多种肿瘤组织和细胞中高表达,并且与侵袭转移相关.由于G3BP与肿瘤细胞的多种生物学特性有关,因此G3BP有望成为一个肿瘤治疗的新靶点.

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