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Advances in the study of polymeric micelles used in oral administration

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Author:
No author available
Journal Title:
ACTA PHARMACEUTICA SINICA
Issue:
5
DOI:
No doi available
Key Word:
聚合物胶束;口服给药;药物传递系统;增溶;polymeric micelle;oral administration;drug delivery system;solubilizing

Abstract: Polymeric micelles which are self-assembled from amphiphilic copolymers are thermodynamically stable, and they can solubilize hydrophobic drugs by the hydrophilic core. Many excellent active compounds are confined because of general low oral bioavallability due to poor solubility. Take into account from the two points above, polymeric miceUes may be used as proper oral carrier to improve the dissolubility of hydrophobic drugs, and enhance the permeation though gastrointestinal tract, therefore, the pharmacodynamics is elevated.Meanwhile, the segments in copolymers are multivariate, so many kinds of miceUes can be obtained, such as,pH- or thermo- sensitive as well as mucoadhesive ones. The modified micelles can alter drug release profiles while solubilizing them, that is why the oral bioavailability increase further. In this review, recent progress of polymeric micelles used in oral administration is summarized, and the prospect of polymeric micelles' application in this field is also evaluated.

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