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Establishment of isolated rabbit airway smooth muscles responsiveness model for the pharmacodynamic study of anti-rhinoviruses drugs

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Author:
No author available
Journal Title:
ACTA PHARMACEUTICA SINICA
Issue:
4
DOI:
No doi available
Key Word:
人鼻病毒;气管平滑肌;呼吸道感染;抗病毒药物筛选;human rhinovirus;airway smooth muscle;respiratory tract infection;anti-viral drug screening

Abstract: Human rhinoviruses(HRVs)are the causative pathogens in more than half of viral upper respiratory tract infections. Currently,no antiviral agents that are active against HRVs are available for clinical use.Because only higher primates are susceptible to HRVs,the screening of new drug is most commonly based on the cell line model. In this study,isolated rabbit airway smooth muscles(ASM)tissue model has been established,and the airway responsiveness with diflferent treatment has been examined. Relative to control tissues,the maximal constrictor(T_(max))response to ACh increased significantly 150%in ASM inoculated with HRV,and relaxation to isoproterenol has been aaenuated to 63%. And the abnormal responsiveness can be inhibited in presence of pretreatment with several new compounds which have been exhibited effeetive anti-HRV activity on eell lines.The results demonstrate that the established ASM model will be applied to screening the anti-HRVs drugs.

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