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Bioactivity diversity and functional mechanism of tetrahydroisoquinoline alkaloids

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Author:: No author available

Journal Title:: ACTA PHARMACEUTICA SINICA

Issue:: 1

DOI:: No doi available

Key Word:: 四氢异喹啉类生物碱;生物活性多样性;作用机制;tetrahydroisoquinoline alkaloids;bioactivity diversity;functional mechanism

Abstract： Tetrahydroisoquinoline alkaloids distributed widely in the nature and some have a broad application in clinic. More attention has been paid in recent years on this type of alkaloid,owing to the diverse range of biological activities exhibited by these alkaloids and the discovery of new functional mechanisms and molecular targets underlying these activities.This article summarized the recent advances in the biological activities and functional mechanism of tetrahydroisoquinoline,which included the activities such as antitumor,antibiotic,antivirus,anti-inflammatory,anticoagulation,bronchodilation,and the action on central nervous system,with the purpose of providing some ideas in the study of biological activity of this type of alkaloid and in the search for lead-compound and rational drug design.

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