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Action of protein phosphatase-1 on Tat-dependent HIV-1 transcription and its related inhibitors
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- Author:
- No author available
- Journal Title:
- ACTA PHARMACEUTICA SINICA
- Issue:
- 12
- DOI:
- 10.3321/j.issn:0513-4870.2009.12.005
- Key Word:
- HIV-1;转录;蛋白磷酸酶1;磷酸化;抑制剂;HIV-1;transcription;protein phosphatase-1;phosphorylation;inhibitor
Abstract： Host cell protein phosphatase-1(PP1)is an important regulator of human immunodeficiency virus-1(HIV-1)transcription.PPl is involved in the regulation of HIV-1 transcription.and dephosphorylates RNA polymerase Ⅱ C-terminal domain(RNAPⅡ CTD)or CycTl-dependent kinase 9(CDK9)to increase Tatdependent HIV-1 transcription.In this review,we discuss the action of PPl in Tat-induced HIV-1 transcription and related to PP1 inhibitors.
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