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Microcalorimetric investigation of two cephalosporins on colon bacteria activity
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- Author:
- No author available
- Journal Title:
- ACTA PHARMACEUTICA SINICA
- Issue:
- 10
- DOI:
- 10.3321/j.issn:0513-4870.2009.10.012
- Key Word:
- 微量量热法;抑制作用;头孢拉定;头孢他定;大肠杆菌
Abstract： 用微量量热法测定了37℃时头孢拉定和头孢他定对大肠杆菌DH5α代谢作用的产热曲线.根据产热曲线,分别得到了大肠杆菌DH5α在不同浓度的头孢拉定和头孢他定作用下的生长速率常数k、抑制率I、最大产热功率Pm以及最大产热功率所对应的时间tm等热动力学参数,从热动力学的角度探讨了头孢拉定和头孢他定对大肠杆菌DH5α代谢作用的影响.实验证明,头孢他定对大肠杆菌的抑制作用比头孢拉定更强.
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