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LEDGF/p75: a novel target for anti-HIV therapy and advances in the study of its related inhibitors

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Author:: No author available

Journal Title:: ACTA PHARMACEUTICA SINICA

Issue:: 9

DOI:: 10.3321/j.issn:0513-4870.2009.09.003

Key Word:: 人类免疫缺陷病毒1型;晶状体上皮源性生长因子;整合酶;抑制剂

Abstract：作用是抑制HIV复制感染的有效途径.而LEDGF/p75与整合酶结合的三维品体结构已被解析,并通过高通量筛选获得了该细胞辅助因子的抑制剂.本文综述了LEDGF/p75的结构功能、与整合酶作用的机制以及基于该细胞辅助因子的抑制剂研究.

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