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A novel target for the regulation of cardiac arrhythmias——microRNAs

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Author:: No author available

Journal Title:: ACTA PHARMACEUTICA SINICA

Issue:: 8

DOI:: 10.3321/j.issn:0513-4870.2009.08.002

Key Word:: microRNA;心律失常;mRNA;离子通道

Abstract： microRNAs(miRNAs)是一类长约22个核苷酸的非编码小分子RNA,通过与靶蛋白mRNA 3'端非编码区的不完全互补结合,抑制靶mRNA转录后的表达.最近大量研究显示miRNA在心脏病理、生理过程中发挥重要的调控作用,尤其与心律失常的发生、发展密切相关.miRNA过度上调或下调可引起离子通道蛋白表达紊乱,致离子通道平衡失调,诱发心律失常.本文将从与心律失常发生相关的心肌缺血、心肌肥厚和糖尿病心肌病三个方面就miRNA在心律失常中的调控作用作一综述.旨在揭示miRNA变化在心脏疾病发生、发展中的重要地位.并探讨以miRNA为靶点防治心律失常以及心源性猝死的可行性.

Reference

[1]龚冬梅,单宏丽,周宇宏,等.哇巴因和乌头碱诱发豚鼠和大鼠心律失常的离子作用靶点[J].2004,(5).
[2]张莹,张勇,蔡本志,等.microRNA在犬心房纤颤模型中的变化[J].2007,(2).
[3]张勇,吕延杰,杨宝峰.MicroRNA在人类疾病中的作用及其作为靶点的小分子药物设计[J].2007,(11).
[4]潘振伟,吕延杰,初文峰,等.缺血性心律失常相关微小RNA在大鼠心脏的表达变化[J].2007,(2).
[5]王志勇,王玲,潘振伟,等.胺碘酮对大鼠心肌梗死后重构心肌细胞钾电流的作用[J].2005,(12).
[6]Sawanobori T,Hiramatsu M,Furukawa T,etc.Ion channel remodeling in cardiac hypertrophy is prevented by blood pressure reduction without affecting heart weight increase in rats with abdominal aortic banding.[J].2002,39(6).
[7]Wang DZ,Deng Z,Callis TE,etc.Muscling through the microRNA world.[J].2008,233(2).
[8]Niu Z,Schwartz RJ,Zhang SX,etc.Serum response factor micromanaging cardiogenesis.[J].2007,19(6).
[9]R C, Lee,R L, Feinbaum,V, Ambros.The C. elegans heterochronic gene lin-4 encodes small RNAs with antisense complementarity to lin-14.[J].1993,75(5).
[10]Carina Gross,Jonathan D,Juergen Soutschek,etc.Microrna-21 Contributes To Myocardial Disease By Stimulating Map Kinase Signalling In Fibroblasts[J].2008,456(7724).
[11]Terentyev D,Terentyeva R,Abdellatif M,etc.miR-1 overexpression enhances Ca(2+) release and promotes cardiac arrhythmogenesis by targeting PP2A regulatory subunit B56alpha and causing CaMKII-dependent hyperphosphorylation of RyR2.[J].2009,104(4).
[12]Robbins J.KCNQ potassium channels: physiology, pathophysiology, and pharmacology.[J].2001,90(1).
[13]Lee Y,Jeon K,Lee JT,etc.MicroRNA maturation: stepwise processing and subcellular localization.[J].2002,21(17).
[14]Hughes TR,Morris Q,Blencowe BJ,etc.Probing microRNAs with microarrays: Tissue specificity and functional inference.[J].2004,10(11).
[15]Luo X,Zhang Y,Yang B,etc.MicroRNA miR-133 represses HERG K+ channel expression contributing to QT prolongation in diabetic hearts.[J].2007,282(17).
[16]Conlon FL,Mandel EM,Chen JF,etc.The role of microRNA-1 and microRNA-133 in skeletal muscle proliferation and differentiation[J].2006,38(2).
[17]Wang WH,Xiao J,Ma WC,etc.Ischemia impairs the association between connexin 43 and M3 subtype of acetylcholine muscarinic receptor (M3-mAChR) in ventricular myocytes[J].2006,17(3).
[18]Tang XQ,Zhuang X,Gal J,etc.A simple array platform for microRNA analysis and its application in mouse tissues[J].2007,13(10).
[19]Yang B,Lin H,Xiao J,etc.The muscle-specific microRNA miR-1 regulates cardiac arrhythmogenic potential by targeting GJA1 and KCNJ2.[J].2007,13(4).
[20]Lagos-Quintana M,Rauhut R,Yalcin A,etc.Identification of tissue-specific microRNAs from mouse[J].2002,12(9).
[21]Mohler PJ,Anderson ME.MicroRNA may have macro effect on sudden death.[J].2007,13(4).
[22]Care A,Catalucci D,Felicetti F,etc.MicroRNA-133 controls cardiac hypertrophy.[J].2007,13(5).
[23]Luo X,Xiao J,Wang Z,etc.Transcriptional activation by stimulating protein 1 and post-transcriptional repression by muscle-specific microRNAs of IKs-encoding genes and potential implications in regional heterogeneity of their expressions.[J].2007,212(2).