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The role of vitagene in aging and Alzheimer's disease and relevant advances of pharmacological study

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Author:: No author available

Journal Title:: ACTA PHARMACEUTICA SINICA

Issue:: 8

DOI:: 10.3321/j.issn:0513-4870.2009.08.001

Key Word:: 衰老;阿尔茨海默病;热休克蛋白;血红素加氧酶;硫氧还蛋白

Abstract：衰老的自由基假说强调了衰老过程中自由基的积累导致细胞损伤.阿尔茨海默病是多发于老年人的以认知和记忆功能障碍为特点的神经退行性疾病.衰老是阿尔茨海默病的关键危险因素.大量证据表明,机体自由基生成和清除平衡的破坏是促进衰老和神经退行性改变的主要原因.脑组织通过诱导一系列基因的表达对抗氧化应激,这些基因被称作生命基因.生命基因的表达产物主要包括热休克蛋白家族、血红素加氧酶系统和硫氧还蛋白系统,他们构成了机体内源性的防御系统.本文综述了生命基因在衰老和阿尔茨海默病脑组织中的表达和功能,以及相关药理学研究.

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