Paper - WANFANG MED ONLINE

You Position: Home > Paper

Progress in the study of micelle delivery system reversing multidrug resistance

( views:9, downloads:0 )

Author:: No author available

Journal Title:: ACTA PHARMACEUTICA SINICA

Issue:: 7

DOI:: 10.3321/j.issn:0513-4870.2009.07.004

Key Word:: 药物传递系统;多药耐药;胶束;脂质体;纳米粒

Abstract：肿瘤多药耐药是目前肿瘤治疗的一大障碍.研究采刚药物传递系统如胶束、脂质体、纳米粒等,以逆转多药耐药,显示其安全可靠,并具有良好的应用前景.本文重点综述了药物传递系统中的聚合物胶束逆转多药耐药的研究结果及其可能的作用机制.随着研究的深入,药物传递系统在逆转肿瘤多药耐药的研究领域将发挥更加重要的作用.

Reference

[1]范青,范广俊,杨佩满,等.丹参酮微乳逆转肿瘤细胞多药耐药的研究[J].2004,(11).
[2]张晓菁,温泽清,张华玲,等.RNA干扰技术抑制耐药细胞MDR1基因表达的研究[J].2006,(5).
[3]陈大为,鄢璐,乔明曦,等.多西他赛pH敏感嵌段共聚物胶束的制备[J].2008,(10).
[4]王坚成,刘晓岩,吕万良,等.新型阿霉素抗耐药性隐形脂质体的体外细胞毒和体内毒性研究[J].2005,(5).
[5]杨锡贵,贾丽雅,魏玲,等.恶性淋巴瘤mdr1和MRP mRNA及 P-gp表达水平与化疗疗效的相关研究[J].2002,(17).
[6]Jun, Wu,Yanhui, Lu,Alice, Lee,etc.Reversal of multidrug resistance by transferrin-conjugated liposomes co-encapsulating doxorubicin and verapamil.[J].2007,10(3).
[7]Ho Lun Wong,Karlo Babakhanian,Reina Bendayan,etc.A Mechanistic Study of Enhanced Doxorubicin Uptake and Retention in Multidrug Resistant Breast Cancer Cells Using a Polymer-Lipid Hybrid Nanoparticle System[J].2006,317(3).
[8]Wen-jing DENG,Xiao-qiang YANG,Yong-Ju Liang,etc.FG020326-1oaded nanoparticle with PEG and PDLLA improved pharma-codynamics of reversing multidrug resistance in vitro and in vivo[J].2007,(6).
[9]T C, Chambers,E M, McAvoy,J W, Jacobs,etc.Protein kinase C phosphorylates P-glycoprotein in multidrug resistant human KB carcinoma cells.[J].1990,265.
[10]Wioland MA,Van Huyen-JP,Lacave R,etc.Tissue and cell distribution of the multidrug resistance-associated protein (MRP) in mouse intestine and kidney.[J].1999,47(6).
[11]Bae YH,Na K,Lee ES.Doxorubicin loaded pH-sensitive polymeric micelles for reversal of resistant MCF-7 tumor[J].2005,103(2).
[12]Kim D,Gao ZG,Lee ES,etc.Super pH-sensitive multifunctional polymeric micelle for tumor pH(e) specific TAT exposure and multidrug resistance[J].2008,129(3).
[13]Batrakova EV.,Alakhov VY.,Kabanov AV..An essential relationship between ATP depletion and chemosensitizing activity of Pluronic((R)) block copolymers[J].2003,91(1).
[14]Kabanov AV,Li S,Kelly DL,etc.Prevention of MDR development in leukemia cells by micelle-forming polymeric surfactant[J].2008,131(3).
[15]Koziara JM,Mumper RJ,Whisman TR,etc.In-vivo efficacy of novel paclitaxel nanoparticles in paclitaxel-resistant human colorectal tumors[J].2006,112(3).
[16]Alakhov VY,Batrakova EV,Kabanov AV.Pluronic block copolymers for overcoming drug resistance in cancer.[J].2002,54(5).
[17]Valery Yu. Alakhov,Elizaveta Yu. Moskaleva,Elena V. Batrakova,etc.Hypersensitization of Multidrug Resistant Human Ovarian Carcinoma Cells by Pluronic P85 Block Copolymer[J].1996,7(2).
[18]Murphy M,Hoffman WH,Zilfou JT,etc.Transcriptional repression of the anti-apoptotic survivin gene by wild type p53.[J].2002,277(5).
[19]Han M,Xu DH,He CX,etc.A novel camptothecin derivative incorporated in nano-carrier induced distinguished improvement in solubility, stability and anti-tumor activity both in vitro and in vivo.[J].2009,26(4).
[20]Bendayan R,Liu Z,Rauth AM,etc.Delivery of an anticancer drug and a chemosensitizer to murine breast sarcoma by intratumoral injection of sulfopropyl dextran microspheres.[J].2003,55(8).
[21]Hu Y,Zheng B,Huang WZ,etc.Influence of SiRNA targeting survivin on chemosensitivity of H460/cDDP lung cancer cells.[J].2008,36(4).
[22]Lee ES,Bae YH,Mohajer G.Enhanced intercellular retention activity of novel pH-sensitive polymeric micelles in wild and multidrug resistant MCF-7 cells.[J].2007,24(9).
[23]Moretti JL,Cordobes MD,de Beco-V,etc.Uptake of liposome-encapsulated 99Tcm-MIBI by sensitive and multidrug-resistant tumour cell lines.[J].1999,20(5).
[24]Kobayashi T,Ise S,Ishida T,etc.Effect of transferrin receptor-targeted liposomal doxorubicin in P-glycoprotein-mediated drug resistant tumor cells.[J].2007,329(1).
[25]Minko T,Li S,Li YL,etc.Pluronic block copolymers alter apoptotic signal transduction of doxorubicin in drug-resistant cancer cells[J].2005,105(3).
[26]Jowle D,Alakhov V,Kerr D,etc.Phase I dose escalation and pharmacokinetic study of pluronic polymer-bound doxorubicin (SP1049C) in patients with advanced cancer.[J].2004,90(11).
[27]Foger F,Hoyer H,Loretz B,etc.Enhanced transport of P-glycoprotein substrate saquinavir in presence of thiolated chitosan.[J].2007,15(2).
[28]Wu C,Fu D,Lv G,etc.In vitro study of drug accumulation in cancer cells via specific association with CdS nanoparticles.[J].2006,16(18).
[29]Gao ZG,Oh KT,Bae YH,etc.Doxorubicin-Loaded Polymeric Micelle Overcomes Multidrug Resistance of Cancer by Double-Targeting Folate Receptor and Early Endosomal pH[J].2008,4(11).
[30]Kwon GS,Lavasanifar A,Adams ML.Amphiphilic block copolymers for drug delivery.[J].2003,92(7).
[31]Sha X,Wang Y,Fang X,etc.Difunctional Pluronic copolymer micelles for paclitaxel delivery: synergistic effect of folate-mediated targeting and Pluronic-mediated overcoming multidrug resistance in tumor cell lines.[J].2007,337(1).
[32]Hoffer M,Werle M.Glutathione and thiolated chitosan inhibit multidrug resistance P-glycoprotein activity in excised small intestine[J].2006,111(1).
[33]Li Y,Batrakova EV,Li S,etc.Effect of pluronic P85 on ATPase activity of drug efflux transporters.[J].2004,21(12).
[34]Chen HL,Chen JL,Liang WQ,etc.Liposomes modified with polycation used for gene delivery: preparation, characterization and transfection in vitro.[J].2007,343(1).
[35]Shenoy D,Amiji M,van Vlerken L,etc.Multi-functional nanocarriers for targeted delivery of drugs and genes[J].2008,130(2).
[36]Yang X,Blanco E,Shuai X,etc.Folate-functionalized polymeric micelles for tumor targeted delivery of a potent multidrug-resistance modulator FG020326.[J].2008,86(1).
[37]Burt H,Zastre J,Iqbal F,etc.Enhanced cellular accumulation of a P-glycoprotein substrate, rhodamine-123, by caco-2 cells using low molecular weight methoxypolyethylene glycol-block-polycaprolactone diblock copolymers.[J].2002,54(3).
[38]Thomas H,Coley HM.Overcoming multidrug resistance in cancer: an update on the clinical strategy of inhibiting p-glycoprotein.[J].2003,10(2).
[39]Liang GW,Li X,Zhang YT,etc.Effect of stealthy liposomal topotecan plus amlodipine on the multidrug-resistant leukaemia cells in vitro and xenograft in mice.[J].2006,36(6).
[40]Kiura K,Harada A,Kojima C,etc.Preparation and cytotoxic activity of poly(ethylene glycol)-modified poly(amidoamine) dendrimers bearing adriamycin.[J].2008,29(11).
[41]Li S,Alakhov VY,Batrakova EV,etc.Sensitization of cells overexpressing multidrug-resistant proteins by pluronic P85.[J].2003,20(10).