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Progress in the research 0f amorphous pharmaceuticals
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- Author:
- No author available
- Journal Title:
- ACTA PHARMACEUTICA SINICA
- Issue:
- 5
- DOI:
- 10.3321/j.issn:0513-4870.2009.05.001
- Key Word:
- 无定型状态;药物吸收;药物疗效;固体药物制剂
Abstract： 固体药物的无定型状态是药物分子排列的无序状态,这种物质状态可能增加药物的生物利用度,促进药物的快速吸收,同时也有可能改变药物的疗效.同一药物的无定型态制剂,在不同的制备工艺下,也可表现出不同的性质.因此,固体药物的无定型状态是新药研发过程中重要的研究内容.然而无定型状态固体物质的稳定性一般较差,有些无定型状态的药物甚至具有潜在的不良反应,成为阻碍药物无定型态应用的障碍.本文主要介绍近年来在药物无定型状态研究领域的进展,探讨影响无定型状态的药物作用的可能因素,分析无定型在药物研发中的应用前景.
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