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Protective effect of propofol against intracerebral hemorrhage injury in rats
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- Author:
- No author available
- Journal Title:
- ACTA PHARMACEUTICA SINICA
- Issue:
- 4
- DOI:
- 10.3321/j.issn:0513-4870.2009.04.004
- Key Word:
- 丙泊酚;脑出血;神经保护作用;抗氧化;propofol;intracerebral hemorrhage;neuroprotective effect;antioxidant CLC number;R965 Document code;A Article
Abstract： The neuroprotective effect of propofol against intracerebral hemorrhage (ICH) in rats was eaudate nucleus.Three doses of propofol were given intraperitoneally (ip) 10 rain before collagenase infusion.Effects of propofol on neurological behavioral scores,brain water content (BWC),activity of superoxide dismutase (SOD) andcontent of malondialdehyde (MDA) in brain tissue,expression level of caspase-3 were studied.In significantly lower than those in ICH group (P＜0.05,P＜0.01),whereas the activity of SOD was higher than dose-dependent manner (r = 0.877).Brain damages caused by ICH in rats can be alleviated by propofol,which mechanism might be attributed to its antioxidant activity.
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