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Multi-target therapeutics and new drug discovery
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- Author:
- No author available
- Journal Title:
- ACTA PHARMACEUTICA SINICA
- Issue:
- 3
- DOI:
- 10.3321/j.issn:0513-4870.2009.03.003
- Key Word:
- 多靶点;联合用药;多组分药物;协同作用
Abstract： 作用于单靶点的药物在治疗复杂性疾病如肿瘤、糖尿病、感染性疾病时常常疗效不佳或毒性较大.多靶点药物可以同时调节疾病网络系统中的多个环节,不易产生抗药性,对各靶点的作用产生协同效应,达到最佳的治疗效果.本文对多靶点药物治疗的特点、分类情况、发现策略、筛选模型及己在临床使用的多靶点治疗药物进行综述,并探讨中药在多靶点药物治疗应用中的潜力.
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