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Application of numerical convolution in in vivo/in vitro correlation research
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- Author:
- No author available
- Journal Title:
- ACTA PHARMACEUTICA SINICA
- Issue:
- 1
- DOI:
- 10.3321/j.issn:0513-4870.2009.01.003
- Key Word:
- 卷积法;体内外相关性;Excel
Abstract： 本文介绍了体内外相关性和卷积法,反卷积法的概念及原理,阐述了采用卷积法使用Excel根据制剂的药代动力学数据计算其在体内释放行为的策略及方法,并用于体内外相关性研究.该法用数学软件对药代动力学数据进行拟合以弥补缺失的数据点,在假设输入函数基本符合威布尔规律的前提下,在Excel中根据卷积法原理以试错法的方式确定拟合度最佳的输入函数(威布尔函数)参数,最后以拟合度最佳的输入函数作为制剂的体内释放行为与体外释放数据进行相关性研究.在实例中不仅详细说明了该法的应用,并且通过与隔室模型法和反卷积法的比较证明此方法简单有效,可以作为体内外相关性研究的有力工具.
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