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Drug discovery based on classic natural products

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Author:: No author available

Journal Title:: ACTA PHARMACEUTICA SINICA

Issue:: 1

DOI:: 10.3321/j.issn:0513-4870.2009.01.002

Key Word:: 药物发现;经典大然产物;作用分子机制;构效关系研究;资源研究

Abstract：利用现代细胞生物学、分子生物学技术开展经典天然产物的分子机制研究,建立合适的体外活性评价模型系统,然后通过药物化学技术进一步研究其结构与活性、结构与毒性、结构与ADME(absorption,distribution,metabolism and excretion)性质的关系,是我国发现具有自主知识产权新药的一条有效途径.

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