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Progress in the study of response surface modeling in investigation of drug-drug interaction in anesthetic drugs

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Author:: No author available

Journal Title:: ACTA PHARMACEUTICA SINICA

Issue:: 12

DOI:: 10.3321/j.issn:0513-4870.2008.12.002

Key Word:: 响应曲面模型;麻醉药物;药物-药物相互作用

Abstract：响应曲面法是一种研究药物-药物相互作用的有效而新颖的方法.当两种药物以不同比例合用时,这种方法可表述药效响应曲面的关键特征,发现曲面中的响应最优区域,揭示药物间相互作用的机制,以达到指导临床合理用药,降低用药风险和用药成本的目的.本文以麻醉药为例介绍了响应曲面法的相关概念、模型结构及其在模型化解析和临床实践中研究的进展.

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