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The action of TSG101 on HIV-1 budding and related inhibitors
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- Author:
- No author available
- Journal Title:
- ACTA PHARMACEUTICA SINICA
- Issue:
- 12
- DOI:
- 10.3321/j.issn:0513-4870.2008.12.001
- Key Word:
- TSG101;HIV-1;UEV;Gag;出芽
Abstract： tsg101 基因是一个抑制肿瘤基因,其翻译产物 TSG101 蛋白具有多重生物学功能.近年来的研究发现,TSG101 蛋白通过与 HIV-1 Gag蛋白结合,辅助 HIV-1 病毒颗粒从被感染细胞中释放出来,这说明 TSG101 可作为一个新的抗 HIV-1 靶点.基于 TSG101 蛋白与 HIV Gag 的相互作用和结构,研究人员设计合成了几类 TSG101 蛋白抑制剂,并通过测定这些抑制剂对 TSG101 蛋白的亲和力,发现其中某些化合物具有比野生型 Gag 更强的 TSG101 蛋白亲和力,值得进一步研究.
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