Paper - WANFANG MED ONLINE

You Position: Home > Paper

Progress in the new nonnucleoside anti-HIV reverse transcriptase inhibitor-DCK

( views:164, downloads:6 )

Author:: No author available

Journal Title:: ACTA PHARMACEUTICA SINICA

Issue:: 10

DOI:: 10.3321/j.issn:0513-4870.2008.10.004

Key Word:: DCK;非核苷类逆转录酶抑制剂;艾滋病;人类免疫缺陷病毒

Abstract： DCK是以天然产物为先导化合物经结构修饰得到的一个高活性抗HIV化合物,其作用机制独特,不同于现有的非核苷类逆转录酶抑制剂,高效低毒,有可能发展成为一类新的抗HIV药物.近年来以它为先导化合物进行了多方面的结构修饰,以期得到药用性质更好的化合物.本文就DCK的发现、结构修饰、构效关系及最新进展予以介绍.

Reference

[1]Lee KH,Xie L,Cosentino LM,etc.Anti-AIDS agents. 37. Synthesis and structure-activity relationships of (3'R,4'R)-(+)-cis-khellactone derivatives as novel potent anti-HIV agents.[J].1999,42(14).
[2]L, Xie,Y, Takeuchi,L M, Cosentino,etc.Anti-AIDS agents. 33. Synthesis and anti-HIV activity of mono-methyl substituted 3',4'-di-O-(-)-camphanoyl-(+)-cis-khellactone (DCK) analogues.[J].1998,8.
[3]Yang ZY,Kilgore N,Xia Y,etc.Anti-AIDS agents. Part 58: Synthesis and anti-HIV activity of 1-thia-di-O-((Formula: see text))-camphanoyl-((Formula: see text))-cis-khellactone (1-thia-DCK) analogues.[J].2004,14(12).
[4]Donglei Yu,Chin-Ho Chen,Arnold Brossi,etc.Anti-AIDS Agents.60.Substituted 3'R,4'R-Di-O-(-)-camphanoyl-2',2'-dimethyldihydropyrano[2,3-f]chromone (DCP) Analogues as Potent Anti-HIV Agents[J].2004,47(16).
[5]Li Huang,Yoshiki Kashiwada,L.Mark Cosentino,etc.3′,4′-Di-o-(-)-camphanoyl-(+)-ciskhellactone and related compounds: A. new class of potent anti-HIV agents[J].1994,4(4).
[6]Hartmuth C. Kolb,Michael S. VanNieuwenhze,K. Barry Sharpless.Catalytic Asymmetric Dihydroxylation[J].1994,94(8).
[7]Xia Y,Yang ZY,Kilgore N,etc.Anti-AIDS agents. Part 56: Synthesis and anti-HIV activity of 7-thia-di-O-(-)-camphanoyl-(+)-cis-khellactone (7-thia-DCK) analogs.[J].2004,12(24).
[8]Jing-yun Li,Hai-feng Chen,Jian-zhou Ma,etc.Molecular modeling, design, synthesis, and biological evaluation of novel 3′,4′-dicamphanoyl-(+)-cis-khellactone (DCK) analogs as potent anti-HIV agents[J].2005,13(23).
[9]Thomas Tung-Ying Lee,Yoshiki Kashiwada,Li Huang,etc.Suksdorfin: an anti-HIV principle from Lomatium suksdorfii, its structure-activity correlation with related coumarins, and synergistic effects with anti-AIDS nucleosides[J].1994,2(10).
[10]Xie L.,Crimminis MT.,Lee KH..Anti-Aids Agents .22. Asymmetric Synthesis of 3',4'-Di-O-(-)-Camphanoyl-(+)-CIS-Khellactone (Dck), a Potent Anti-Hiv Agent[J].1995,36(26).
[11]RC Gallo,PS Sarin,EP Gelmann,etc.Isolation of human T-cell leukemia virus in acquired immune deficiency syndrome (AIDS)[J].1983,220 (4599).
[12]Zheng-Yu Yang,Yi Xia,Peng Xia,etc.Anti-AIDS agents 31.1 synthesis and anti-HIV activity of 4-substituted 3′,4′-di-O-(-)-camphanoyl-(+)-cis-khellactone (DCK) thiolactone analogs[J].1998,8(12).
[13]Philip C. Smith,Carl Wild,Graham Allaway,etc.Anti-AIDS Agents. 52. Synthesis and Anti-HIV Activity of Hydroxymethyl (3'R,4'R)-3',4'-Di-O-(S)-camphanoyl-(+)-cis-khellactone Derivatives[J].2004,47(3).
[14]Suzuki M,Lee KH,Smith PC,etc.Anti-AIDS agents 66: syntheses and anti-HIV activity of phenolic and aza 3',4'-di-O-(-)-camphanoyl-(+)-cis-khellactone (DCK) derivatives.[J].2007,15(21).
[15]Xia P,Lee KH,Cosentino LM,etc.Anti-AIDS agents part 41: synthesis and anti-HIV activity of 3',4'-di-o-(-)-camphanoyl-(+)-cis-khellactone (DCK) lactam analogues.[J].2000,10(10).
[16]Li Huang,Yoshiki Kashiwada,L. Mark Cosentino,etc.Anti-AIDS Agents. 15. Synthesis and Anti-HIV Activity of Dihydroseselins and Related Analogs[J].1994,37(23).
[17]Xie L,Allaway G,Kilgore N,etc.Anti-AIDS agents. Part 47:(dagger) synthesis and anti-HIV activity of 3-substituted 3',4'-Di-O-(S)-camphanoyl-(3'R,4'R)-(+)-cis-khellactone derivatives.[J].2001,11(17).
[18]Lee KH,McPhail AT,Cosentino LM,etc.Anti-AIDS agents. 42. Synthesis and anti-HIV activity of disubstituted (3'R,4'R)-3',4'-di-O-(S)-camphanoyl-(+)-cis-khellactone analogues.[J].2001,44(5).
[19]Lee KH,Yu DL,Huang L,etc.Mechanism of action and resistant profile of anti-HIV-1 coumarin derivatives[J].2005,332(2).
[20]Yasuo Takeuchi,Lan Xie,L.Mark Cosentino,etc.Anti-AIDS agents-XXVIII.1 Synthesis and Anti-HIV activity of methoxy substituted 3′,4′-Di-O-(-)-camphanoyl-(+)-cis-khellactone (DCK) analogues[J].1997,7(20).